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Titolo:
beta-phenylethylidenehydrazine, a novel inhibitor of GABA transaminase
Autore:
Paslawski, T; Knaus, E; Iqbal, N; Coutts, RT; Baker, GB;
Indirizzi:
Univ Alberta, Dept Psychiat, Neurochem Res Unit, Walter Mackenzie Hlth SciCtr, Edmonton, AB T6G 2R7, Canada Univ Alberta Edmonton AB Canada T6G 2R7 Ctr, Edmonton, AB T6G 2R7, Canada Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada Univ Alberta Edmonton AB Canada T6G 2N8 Sci, Edmonton, AB T6G 2N8, Canada
Titolo Testata:
DRUG DEVELOPMENT RESEARCH
fascicolo: 1, volume: 54, anno: 2001,
pagine: 35 - 39
SICI:
0272-4391(200109)54:1<35:BANIOG>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-VINYL GABA; ANTIDEPRESSANT/ANTIPANIC DRUG PHENELZINE; MITOCHONDRIAL MONOAMINE-OXIDASE; TRANSIENT FOREBRAIN ISCHEMIA; RAT-BRAIN GABA; PANIC DISORDER; ANXIOLYTIC-LIKE; VALPROATE; OXIDATION;
Keywords:
gamma-aminobutyric acid (GABA); GABA transaminase; monoamine oxidase; phenylethylidenehydrazine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Baker, GB Univ Alberta, Dept Psychiat, Neurochem Res Unit, Walter Mackenzie Hlth SciCtr, Edmonton, AB T6G 2R7, Canada Univ Alberta Edmonton AB Canada T6G 2R7 ton, AB T6G 2R7, Canada
Citazione:
T. Paslawski et al., "beta-phenylethylidenehydrazine, a novel inhibitor of GABA transaminase", DRUG DEV R, 54(1), 2001, pp. 35-39

Abstract

Phenylethylidenehydrazine (PEH), a proposed metabolite of phenelzine (PLZ), was synthesized in our laboratories and administered to rats in a series of time- and dose-response studies. Phenelzine is a monoamine oxidase (MAO)inhibiting antidepressant/antipanic drug that also causes marked elevations of brain levels of the inhibitory neurotransmitter (gamma -aminobutyric acid (GABA). Like PLZ, PEH inhibited GABA transaminase (GABA-T) and caused marked, long-lasting increases in rat brain levels of GABA. The addition of the double bond in PEH caused a marked decrease in its ability to inhibit MAO compared to PLZ. Given the ability of PEH to elevate GABA levels and itslack of significant effect on MAO, it may be a very effective and safe tool with which to study the role of GABA in anxiety disorders and may be a potentially useful compound to test against seizures, ischemia, mania, and stroke. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:21:29