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Titolo:
The subjective effects of MDMA and mCPP in moderate MDMA users
Autore:
Tancer, ME; Johanson, CE;
Indirizzi:
Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Subst Abuse ResDiv, Detroit, MI 48207 USA Wayne State Univ Detroit MI USA 48207 Abuse ResDiv, Detroit, MI 48207 USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 1, volume: 65, anno: 2001,
pagine: 97 - 101
SICI:
0376-8716(200112)65:1<97:TSEOMA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; M-CHLOROPHENYLPIPERAZINE; ECSTASY; HUMANS; NEUROENDOCRINE; PHENMETRAZINE; AMPHETAMINE; RESPONSES;
Keywords:
3,4-methylenedioxymethamphetamine; meta-chlorophenylpiperazine; hallucinogenic rating scale;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Tancer, ME Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Subst Abuse ResDiv, Detroit, MI 48207 USA Wayne State Univ Detroit MI USA 48207 v, Detroit, MI 48207 USA
Citazione:
M.E. Tancer e C.E. Johanson, "The subjective effects of MDMA and mCPP in moderate MDMA users", DRUG AL DEP, 65(1), 2001, pp. 97-101

Abstract

The present study is part of a research program designed to better understand the neurochemical mechanisms underlying the abuse liability of 3,4-methylenedioxymethamphetamine (MDMA) in humans. In these studies, MDMA will be compared to prototypical dopamine (D-amphetamine) and serotonin (meta-chlorophenylpiperazine, mCPP) releasing agents on a variety of measures related to dependence. In order to determine an acceptable dose range (safe but active) of MDMA and mCPP for these studies, moderate MDMA users were administered escalating doses of MDMA (75, 110 and 145 mg/70 kg) and mCPP (17.5, 35 and 52.5 mg/70 kg). Each participant received a single dose under controlled laboratory conditions, i.e. this was a six-group design with a separate group for each dose. There were five participants tested in each group. MDMAincreased blood pressure and heart rate whereas mCPP had no effect on these physiological measures. MDMA produced increases in subjective effects indicative of both stimulant (increases in POMS Elation, ARCI Amphetamine, VASHigh and Stimulated scale scores) and hallucinogenic effects (increases onfive of the six scales of the Hallucinogenic Rating Scale). mCPP produced similar stimulant effects (e.g. increases on POMS Elation, VAS High and Stimulated), as well as hallucinogenic effects (four of the six scales of the Hallucinogenic Rating Scale), which has not been observed in previous studies. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:36:52