Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Reinforcing and discriminative-stimulus effects of ephedrine isomers in rhesus monkeys
Autore:
Anderson, KG; Winger, G; Woods, J; Woolverton, WL;
Indirizzi:
Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 Human Behav, Jackson, MS 39216 USA Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Pharmacol, Ann Arbor, MI 48109 USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 1, volume: 65, anno: 2001,
pagine: 45 - 53
SICI:
0376-8716(200112)65:1<45:RADEOE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
THE-COUNTER STIMULANTS; RATS; CAFFEINE; COMBINATIONS; AMPHETAMINE; METHAMPHETAMINE; (-)EPHEDRINE; DOPAMINE; BINARY; CUE;
Keywords:
self-administration; drug discrimination; ephedrine; pseudoephedrine; rhesus monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Woolverton, WL Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, 2500 N State St, Jackson, MS 39216 USA Univ Mississippi 2500 N State St Jackson MS USA 39216 6 USA
Citazione:
K.G. Anderson et al., "Reinforcing and discriminative-stimulus effects of ephedrine isomers in rhesus monkeys", DRUG AL DEP, 65(1), 2001, pp. 45-53

Abstract

Ephedrine is a sympathomimetic drug that is currently found in many over-the-counter preparations. This compound exists as four isomers which. in addition to a racemic mixture, were evaluated for their positive reinforcing effects and for their similarity to (+)-amphetamine as a discriminative stimulus. Rhesus monkeys (N=3) with intravenous cocaine (0.1 mg/kg/inj) or saline as a consequence for lever pressing were shown to self-administer all ofthe ephedrine compounds (range tested: 0.03-3.0 mg/kg/inj), with the exception of (-)-pseudoephedrine, when each drug/dose was substituted for cocaine or saline during test sessions. However, the (-)-pseudoephedrine isomer was evaluated within a limited dose range due to solubility limitations. Systematically increasing the number of responses required for an injection indicated that these isomers were not as effective as reinforcers as was cocaine. Rhesus monkeys (N=3) trained to discriminate intragastric 1.0 mg/kg (+)-amphetamine from saline were given substitution tests with the ephedrine isomers and the racemic mixture. When given intragastrically, at least one dose of all the ephedrine isomers substituted for the (+)-amphetamine discriminative stimulus in at least one of the subjects tested. However, (+)-amphetamine-like effects were not systematically related to dose, When the discriminative-stimulus effects of (-)-ephedrine were also compared with thoseof (+)-amphetamine across three different routes of administration, full, dose-related, (+)-amphetamine-like responding was observed with both the intramuscular and intravenous routes. Taken together, these results suggest that the ephedrines have psychomotor stimulant-like abuse potential, lower than that of cocaine. Parenteral administration may enhance psychomotor-stimulant-like effects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:21:55