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Titolo:
Influence of brain catalase on ethanol-induced loss of righting reflex in mice
Autore:
Correa, M; Sanchis-Segura, C; Aragon, CMG;
Indirizzi:
Univ Jaume I, Area Psicobiol, Castello 12080, Spain Univ Jaume I Castello Spain 12080 Area Psicobiol, Castello 12080, Spain
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 1, volume: 65, anno: 2001,
pagine: 9 - 15
SICI:
0376-8716(200112)65:1<9:IOBCOE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; RAT-BRAIN; ACATALASEMIC MICE; ACETALDEHYDE; METABOLISM;
Keywords:
ethanol; catalase; loss of righting reflex; lead acetate; 3-amino-1, 2, 4-triazole; acetaldehyde;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Aragon, CMG Univ Jaume I, Area Psicobiol, Campus Crta Borriol,Apartado 224, Castello 12080, Spain Univ Jaume I Campus Crta Borriol,Apartado 224 Castello Spain 12080
Citazione:
M. Correa et al., "Influence of brain catalase on ethanol-induced loss of righting reflex in mice", DRUG AL DEP, 65(1), 2001, pp. 9-15

Abstract

The effect of lead acetate and 3-amino-1, 2, 4-triazole (AT) on ethanol-induced loss of righting reflex (LORR) and brain catalase activity was studied in an attempt to confirm earlier observations on the involvement of catalase in ethanol-induced effects. Lead acetate (0 or 100 mg/kg) or AT (0 or 500 mg/kg) was injected (acutely) into mice 7 days or 5 h before testing. Other mice were exposed to drinking fluid containing 500 ppm lead acetate for60 days. On the test day, mice received an intraperitoneal injection of ethanol (4.0 or 4.5 g/kg) and the duration of LORR was recorded. Acute lead-treated animals demonstrated a reduction in the duration of the LORR, However, both chronic administration of lead acetate and AT treatment increased the duration of ethanol-produced LORR. Furthermore, brain catalase activity in acute lead pretreated animals showed a significant induction, whereas itwas reduced in chronic lead and AT treated mice. These results suggest that brain catalase activity, and by implication centrally formed acetaldehyde, may modulate ethanol-induced LORR. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 26/01/20 alle ore 10:22:15