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Titolo:
Improving opportunities for effective management of gastro-oesophageal reflux disease
Autore:
Vigneri, S; Tonini, M; Scarpignato, C; Savarino, V;
Indirizzi:
Univ Palermo, Dept Internal Med, Div Gastroenterol, I-90127 Palermo, ItalyUniv Palermo Palermo Italy I-90127 Gastroenterol, I-90127 Palermo, Italy Univ Pavia, Dept Physiol & Pharmacol Sci, I-27100 Pavia, Italy Univ PaviaPavia Italy I-27100 iol & Pharmacol Sci, I-27100 Pavia, Italy Univ Parma, Lab Clin Pharmacol, Dept Internal Med, I-43100 Parma, Italy Univ Parma Parma Italy I-43100 , Dept Internal Med, I-43100 Parma, Italy Univ Genoa, Div Gastroenterol, Dept Internal Med, Genoa, Italy Univ GenoaGenoa Italy v Gastroenterol, Dept Internal Med, Genoa, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 8, volume: 33, anno: 2001,
pagine: 720 - 730
SICI:
1590-8658(200111)33:8<720:IOFEMO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTON-PUMP INHIBITORS; ACID-RELATED DISORDERS; SYMPTOMATIC GASTROESOPHAGEAL REFLUX; QUALITY-OF-LIFE; DOUBLE-BLIND; PRIMARY-CARE; PHARMACOLOGICAL PROPERTIES; MAINTENANCE TREATMENT; GENERAL-PRACTICE; NATURAL-HISTORY;
Keywords:
esomeprazole; gastro-oesophageal reflux disease; proton pump inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Vigneri, S Univ Palermo, Dipartimento Med Clin & Patol Emergenti, Via del Vespro 143,I-90127 Palermo, Italy Univ Palermo Via del Vespro 143 Palermo Italy I-90127 o, Italy
Citazione:
S. Vigneri et al., "Improving opportunities for effective management of gastro-oesophageal reflux disease", DIG LIVER D, 33(8), 2001, pp. 720-730

Abstract

The: recent introduction of proton pump inhibitors has extraordinarily improved the therapeutic approach to gastro-oesophageal reflux disease. The concept of decreasing gastric acid secretion and increasing the pH in the lower oesophagus has been demonstrated to be thera.. peutically effective and the higher the level of pH achieved, the better the results. In spite of the evident efficacy of these molecules, there ara still many patients who will continue to have symptoms despite medical treatment. Proton pump inhibitors suppress gastric acidity, but this effect shows a remarkable intel-individual variation depending on different reasons. Thus, it is still possibleto optimise medical therapy for gastro-oesophageal reflux disease. Esomeprazole, the S-isomer of omeprazole, has an advantageous metabolism and this particular-feature translates into superior clinical efficacy. Clinical trials for initial and long-term treatment across the gastro-oesophageal reflux disease spectrum, have clearly demonstrated the superiority of esomeprazole over omeprazole, even if tolerability and safety are very similar.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:27:12