Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Intrahepatic hepatitis C virus replication is increased in patients with regular alcohol consumption
Autore:
Romero-Gomez, M; Grande, L; Nogales, MC; Fernandez, M; Chavez, M; Castro, M;
Indirizzi:
Hosp Univ Valme, Hepatol Unit, Seville, Spain Hosp Univ Valme Seville Spain Univ Valme, Hepatol Unit, Seville, Spain Hosp Univ Valme, Microbiol Unit, Seville, Spain Hosp Univ Valme Seville Spain niv Valme, Microbiol Unit, Seville, Spain Hosp Univ Valme, Radiol Unit, Seville, Spain Hosp Univ Valme Seville Spain p Univ Valme, Radiol Unit, Seville, Spain
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 8, volume: 33, anno: 2001,
pagine: 698 - 702
SICI:
1590-8658(200111)33:8<698:IHCVRI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPETITIVE REVERSE TRANSCRIPTION; POLYMERASE CHAIN-REACTION; LIVER-TRANSPLANTATION; RNA LEVELS; HCV RNA; QUANTITATION; INFECTION; CIRRHOSIS; TISSUE; SERUM;
Keywords:
alcohol; amplicor-HCV-monitor; grading; hepatitis C virus; intrahepatic HCV levels; serum HCV RNA; staging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Romero-Gomez, M C Juan Antonio Cavestany 1-4 G, Seville 41003, Spain C Juan Antonio Cavestany 1-4 G Seville Spain 41003 Spain
Citazione:
M. Romero-Gomez et al., "Intrahepatic hepatitis C virus replication is increased in patients with regular alcohol consumption", DIG LIVER D, 33(8), 2001, pp. 698-702

Abstract

Aims. To assess clinical significance of liver hepatitis C virus PNA levels and their relationship with epidemiological, biochemical and histologicalfactors. Methods. A total of 50 patients (mean age 35.5 +/-7 years) with biopsy-proven chronic hepatitis C infection were recruited. Risk factors were drug abuse [n=21], transfusion [n=16], other parental routes (n=B; surgery=3, tattooing=5], and idiopathic [n=5]. Duration of infection was 16 +/-9 years. All patients showed abnormal alanine aminotransferase levels and positive serum hepatitis C virus RNA. Hepatitis C virus genotype was assessed by Inno-Lipa. Liver biopsy was performed for histology and for hepatitis C virus PNAquantification by Amplicor-HCV-Monitor Daily alcohol consumption was recorded on two occasions by anamnesis. Inflammation grade was mild [n=31] or severe [n= 19]. Fibrosis was early stage [n=42] or advanced [n=B]. Results. Mean hepatitis C virus PNA levels were 9.4x10(5)+/-1.5x10(6) copies/mug of total PNA in liver tissue, and 9.1x10(6 +/-)1.3x10(6) copies/ml in serum. Viral load in liver was positively correlated with that in serum [r=0.51, p <0.001] and there was a significant relationship between daily alcohol consumption and intrahepatic hepatitis C virus burden [r=0.53; p<0.001]. Patients infected with genotype 3a showed lower intrahepatic hepatitis C virus load than patients infected with genotype 1b; albeit without reaching statistical significance [0.49x10(6)<plus/minus>0.89x10(6) vs 1.44x10(6)/-1.9x10(6) copies/mug of total PNA; p=NS]. No relationships were observedbetween liver viral burden and age, risk factor status, duration of infection, ferritin and alanine aminotransferase levels or with grading and staging. Conclusions. Hepatitis C virus load in serum is a mirror of intrahepatic hepatitis C virus levels. Chronic alcohol consumption enhances intrahepatic hepatitis C virus concentration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:11:31