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Titolo:
Intestinal permeability in Crohn's disease patients and their first degreerelatives
Autore:
Secondulfo, M; de Magistris, L; Fiandra, R; Caserta, L; Belletta, M; Tartaglione, MT; Riegler, G; Biagi, F; Corazza, GR; Carratu, R;
Indirizzi:
SUN, Cattedra Gastroenterol, Gastroenterol Unit, I-80131 Naples, Italy SUN Naples Italy I-80131 erol, Gastroenterol Unit, I-80131 Naples, Italy Univ Pavia, Policlin San Matteo, IRCCS, Gastroenterol Unit, I-27100 Pavia,Italy Univ Pavia Pavia Italy I-27100 , Gastroenterol Unit, I-27100 Pavia,Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 8, volume: 33, anno: 2001,
pagine: 680 - 685
SICI:
1590-8658(200111)33:8<680:IPICDP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELIAC-DISEASE; DIABETES-MELLITUS; TIGHT JUNCTIONS; MANNITOL; CHILDREN; TESTS; RELAPSE; DAMAGE; SUGARS; POUCH;
Keywords:
ASCA; Crohn's disease; intestinal permeability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Carratu, R SUN, Cattedra Gastroenterol, Gastroenterol Unit, Piazza Miraglia 1, I-80131 Naples, Italy SUN Piazza Miraglia 1 Naples Italy I-80131 80131 Naples, Italy
Citazione:
M. Secondulfo et al., "Intestinal permeability in Crohn's disease patients and their first degreerelatives", DIG LIVER D, 33(8), 2001, pp. 680-685

Abstract

Background. Family studies suggested that an altered intestinal permeability plays a role in the genesis of Crohn's disease. Aim. Aim of the present study was to investigate a possible genetic alteration of the mucosal barrier in Crohn's disease.. Subjects. 16 Crohn's disease patients and 26 of their cohabiting first degree relatives were studied. Methods. To investigate intestinal permeability Cellobiose/Mannitol test was administered to both groups. Results. In the two groups, we found that the median intestinal permeability values were higher and statistically different from those obtained in 32healthy control subjects as well as in five healthy control families. Six (37.5%) Crohn's disease patients and three (11.5%) of their first degree relatives showed increased individual intestinal permeability values. Intestinal permeability alteration in Crohns disease patients was unrelated to sex, age, disease activity, localisation, duration, treatment schedule, as well as to serum anti-Saccharomyces cervisiae antibody positivity in a pilot study conducted in 7 Crohn's disease patients; anti-Saccharomyces cervisiae antibody values were negative in all 10 first degree relatives investigated. Conclusions. These findings demonstrate the increase in IP in 37% of the patients and in 11 % of their relatives. More extensive investigation of thecorrelation between ASCA alterations and IP will be needed in both patients with Crohn's disease and their relatives.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:23:51