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Titolo:
Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice
Autore:
Castaing, M; Peault, B; Basmaciogullari, A; Casal, I; Czernichow, P; Scharfmann, R;
Indirizzi:
Hop Robert Debre, INSERM, U457, F-75019 Paris, France Hop Robert Debre Paris France F-75019 NSERM, U457, F-75019 Paris, France Hop Paul Brousse, INSERM, U506, Villejuif, France Hop Paul Brousse Villejuif France usse, INSERM, U506, Villejuif, France
Titolo Testata:
DIABETOLOGIA
fascicolo: 11, volume: 44, anno: 2001,
pagine: 2066 - 2076
SICI:
0012-186X(200111)44:11<2066:BGNUTO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-FETAL PANCREAS; NUDE-MICE; ISLET TRANSPLANTATION; ENDODERM DEVELOPMENT; DIABETES-MELLITUS; IN-VITRO; DIFFERENTIATION; TISSUE; GROWTH; COEXPRESSION;
Keywords:
pancreas; human; embryonic; development; growth; differentiation; islet cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Scharfmann, R Hop Robert Debre, INSERM, U457, 48 Bd Serurier, F-75019 Paris, France Hop Robert Debre 48 Bd Serurier Paris France F-75019 France
Citazione:
M. Castaing et al., "Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice", DIABETOLOG, 44(11), 2001, pp. 2066-2076

Abstract

Aims/hypothesis. Transplanting human pancreatic islet beta cells could represent a radical new treatment of Type I (insulin-dependent) diabetes mellitus. However, beta cells available for grafting are scarce and finding new sources of such cells would be crucial for any cell therapy for diabetes. Undifferentiated precursor cells present in the human embryonic pancreas could represent such a source. Methods. We grafted human embryonic pancreases (6-9 weeks of development) that contain very few beta cells onto NOD/scid mice. Results. The human pancreatic tissue grew, increasing in weight 200 times within six months and endocrine cells differentiated, the number of human beta cells being increased by a factor 5000. Finally, the developed human endocrine tissue was mature enough to control the glycaemia of mice deficientin endogenous beta cells. Conclusion/interpretation. Human embryonic pancreas represent a source of immature cells that can proliferate and differentiate into mass beta cells after transplantation. Transplantation of human embryonic pancreas into NOD/scid mice is a useful model for understanding the development of the humanpancreas during prenatal life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:08:55