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Titolo:
Space flight affects magnocellular supraoptic neurons of young prepuberal rats: transient and permanent effects
Autore:
Garcia-Ovejero, D; Trejo, JL; Ciriza, I; Walton, KD; Garcia-Segura, LM;
Indirizzi:
CSIC, Inst Cajal, E-28002 Madrid, Spain CSIC Madrid Spain E-28002CSIC, Inst Cajal, E-28002 Madrid, Spain NYU, Dept Physiol, New York, NY 10016 USA NYU New York NY USA 10016NYU, Dept Physiol, New York, NY 10016 USA
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 130, anno: 2001,
pagine: 191 - 205
SICI:
0165-3806(20011024)130:2<191:SFAMSN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMO-NEUROHYPOPHYSEAL SYSTEM; VASOPRESSIN GENE-EXPRESSION; CHRONIC ALCOHOL-CONSUMPTION; FOS MESSENGER-RNA; C-FOS; ULTRASTRUCTURAL-CHANGES; SIMULATED WEIGHTLESSNESS; NEUROSECRETORY NEURONS; HYBRIDIZATION ANALYSIS; POSTERIOR PITUITARY;
Keywords:
arginine-vasopressin; oxytocin; supraoptic nucleus; postnatal development; space flight; c-fos; microgravity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia-Ovejero, D CSIC, Inst Cajal, Avda Doctor Arce 37, E-28002 Madrid, Spain CSIC Avda Doctor Arce 37 Madrid Spain E-28002 id, Spain
Citazione:
D. Garcia-Ovejero et al., "Space flight affects magnocellular supraoptic neurons of young prepuberal rats: transient and permanent effects", DEV BRAIN R, 130(2), 2001, pp. 191-205

Abstract

Effects of microgravity on postural control and volume of extracellular fluids as well as stress associated with space flight may affect the functionof hypothalamic neurosecretory neurons. Since environmental modifications in young animals may result in permanent alterations in neuroendocrine function, the present study was designed to determine the effect of a space flight on oxytocinergic and vasopressinergic magnocellular hypothalamic neurons of prepuberal rats. Fifteen-day-old Sprague-Dawley female rats were flownaboard the Space Shuttle Columbia (STS-90, Neurolab mission, experiment 150) for 16 days. Age-matched litters remained on the ground in cages similiar to those of the flight animals. Six animals from each group were killed on the day of landing and eight animals from each croup were maintained under standard vivarium conditions and killed 18 weeks after landing. Several signs of enhanced transcriptional and biosynthetic activity were observed inmagnocellular supraoptic neurons of flight animals on the day of landing compared to control animals. These include increased c-Fos expression, larger nucleoli and cytoplasm, and higher volume occupied in the neuronal perikaryon by mitochondriae, endoplasmic reticulum, Golgi apparatus, lysosomes and cytoplasmic inclusions known as nematosomes. In contrast, the volume occupied by neurosecretory vesicles in the supraoptic neuronal perikarya was significantly decreased in flight rats. This decrease was associated with a significant decrease in oxytocin and vasopressin immunoreactive levels, suggestive of an increased hormonal release. Vasopressin levels, cytoplasmic volume and c-Fos expression returned to control levels by 18 weeks after landing. These reversible effects were probably associated to osmotic stimuli resulting from modifications in the volume and distribution of extracellularfluids and plasma during flight and landing. However, oxytocin levels werestill reduced at 18 weeks after landing in flight animals compared to controls. This indicates that space flight during prepuberal age may induce irreversible modifications in the regulation of oxytocinergic neurons, which in turn may result in permanent endocrine and behavioral impairments. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:37:47