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Titolo:
Early maternal separation alters neuropeptide Y concentrations in selectedbrain regions in adult rats
Autore:
Jimenez-Vasquez, PA; Mathe, AA; Thomas, JD; Riley, EP; Ehlers, CL;
Indirizzi:
St Gorans Univ Hosp, Karolinska Inst, Inst Clin Neurosci, Dept Psychiat, S-11281 Stockholm, Sweden St Gorans Univ Hosp Stockholm Sweden S-11281 , S-11281 Stockholm, Sweden Scripps Clin & Res Inst, Dept Neuropharmacol, La Jolla, CA USA Scripps Clin & Res Inst La Jolla CA USA Neuropharmacol, La Jolla, CA USA San Diego State Univ, Ctr Behav Teratol, San Diego, CA 92182 USA San DiegoState Univ San Diego CA USA 92182 atol, San Diego, CA 92182 USA
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 1-2, volume: 131, anno: 2001,
pagine: 149 - 152
SICI:
0165-3806(20011126)131:1-2<149:EMSANY>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARCUATE NUCLEUS; WISTAR;
Keywords:
neuropeptide Y; maternal separation; depression; brain; trait marker;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Mathe, AA St Gorans Univ Hosp, Karolinska Inst, Inst Clin Neurosci, Dept Psychiat, S-11281 Stockholm, Sweden St Gorans Univ Hosp Stockholm Sweden S-11281 Stockholm, Sweden
Citazione:
P.A. Jimenez-Vasquez et al., "Early maternal separation alters neuropeptide Y concentrations in selectedbrain regions in adult rats", DEV BRAIN R, 131(1-2), 2001, pp. 149-152

Abstract

Human and animal studies support the involvement of neuropeptide Y (NTY) in the pathophysiology of depression. Thus, hippocampal NPY-LI is decreased in genetic models of depression, the Flinders Sensitive Line and Fawn Hooded rats. Maternal 'deprivation' has been identified as one risk factor in the development of psychopathology, including depression in adulthood. In view of these findings we hypothesized that brain NTY may also be decreased inan animal model of early life maternal deprivation. To test this hypothesis, male and female Sprague-Dawley rats were maternally separated (MS) 6 h/day or briefly handled from postnatal day 2 (PN2) to PN6 and from PN9 to PN13. At 12 weeks of age the rats were sacrificed, the brains dissected and NPY-Ll measured by radioimmunoassay. MS rats had lower NTY-LI in the hippocampus. NPY-LI was also lower in female compared to male rats in hippocampus. Lastly, NTY-LI was increased in the hypothalamus of both male and female MSrats. These findings support the hypothesis that altered NPY in the limbicre.-ion is a common denominator of several models of depression and might be a trait marker of vulnerability to affective disorders. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 19/01/20 alle ore 06:17:14