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Titolo:
Cocaine- and amphetamine-regulated transcript peptide-immunoreactivity in dorsal motor nucleus of the vagus neurons of immature rats
Autore:
Dun, SL; Castellino, SJ; Yang, J; Chang, JK; Dun, NJ;
Indirizzi:
E Tennessee State Univ, James H Quillen Coll Med, Dept Pharmacol, Johnson City, TN 37614 USA E Tennessee State Univ Johnson City TN USA 37614 hnson City, TN 37614 USA Phoenix Pharmaceut Inc, Belmont, CA 94002 USA Phoenix Pharmaceut Inc Belmont CA USA 94002 ut Inc, Belmont, CA 94002 USA
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 1-2, volume: 131, anno: 2001,
pagine: 93 - 102
SICI:
0165-3806(20011126)131:1-2<93:CAATPI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CART PEPTIDES; IMMUNOHISTOCHEMICAL LOCALIZATION; CHOLINE-ACETYLTRANSFERASE; SPINAL-CORD; SATIETY; MEDULLA; NERVE; BRAIN;
Keywords:
choline acetyltransferase; medulla oblongata; ingestive behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Dun, SL E Tennessee State Univ, James H Quillen Coll Med, Dept Pharmacol, POB 70577, Johnson City, TN 37614 USA E Tennessee State Univ POB 70577 Johnson City TN USA 37614 614 USA
Citazione:
S.L. Dun et al., "Cocaine- and amphetamine-regulated transcript peptide-immunoreactivity in dorsal motor nucleus of the vagus neurons of immature rats", DEV BRAIN R, 131(1-2), 2001, pp. 93-102

Abstract

Cocaine- and amphetamine-regulated transcript (CART) peptide, a family of neuropeptides, is shown to inhibit food intake upon intracerebroventricularinjection to the rat. CART peptide-immunoreactivity (irCART) was detected in neurons of the dorsal motor nucleus of the vagus (DMNV) of postnatal dayone (Pl) rats, the earliest day examined. The number of labeled DMNV neurons reached the peak between P5 and P8 rats and gradually declined thereafter. Few irCART neurons were noted in the DM-NV between P22 and P90 rats. Double-labeling the medullary sections from P5 and P8 rats with CART-antiserumand choline acetyltransferase (ChAT)-antiserum revealed that irCART neurons in the DMNV were ChAT-immunoreactive (irChAT), but not all irChAT neuronswere irCART. Intraperitoneal injection of the retrograde tracer Fluorogoldto P3 and P5 rats labeled DMNV neurons, the majority of which were also irCART. The number of irCART neurons in other regions of the brain and spinalcord generally showed an increase in adult rats as compared to that of thesame regions in immature rats. Our result suggests that expression of irCART in DMNV neurons undergoes developmental changes such that few neurons appear to contain irCART in mature rats. As a corollary, CART may be a signaling molecule to the gastrointestinal tract during the critical period of early development. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/09/20 alle ore 09:32:06