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Titolo:
Fetal behavioural state changes following maternal fluoxetine infusion in sheep
Autore:
Morrison, JL; Chien, C; Gruber, N; Rurak, D; Riggs, W;
Indirizzi:
Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada BC Res Inst Childrens & Womens Hlth, Dept Obstet & Gynaecol, Vancouver, BCV5Z 4H4, Canada BC Res Inst Childrens & Womens Hlth Vancouver BC Canada V5Z 4H4 4, Canada
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 1-2, volume: 131, anno: 2001,
pagine: 47 - 56
SICI:
0165-3806(20011126)131:1-2<47:FBSCFM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; CARDIOVASCULAR-RESPONSES; ELECTROCORTICAL ACTIVITY; RESPIRATORY MOVEMENTS; PROLONGED HYPOXEMIA; BREATHING MOVEMENTS; HYPOXIC INHIBITION; DEPRESSED-PATIENTS; MAJOR DEPRESSION; BIRTH OUTCOMES;
Keywords:
fetal behavioral states; fluoxetine; uterine artery blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Riggs, W Univ British Columbia, Fac Pharmaceut Sci, 2146 East Mall, Vancouver, BC V6T 1Z3, Canada Univ British Columbia 2146 East Mall Vancouver BC Canada V6T 1Z3
Citazione:
J.L. Morrison et al., "Fetal behavioural state changes following maternal fluoxetine infusion in sheep", DEV BRAIN R, 131(1-2), 2001, pp. 47-56

Abstract

Clinical depression is diagnosed in 5-15% of women during pregnancy, increasing the risk of negative outcomes. Fluoxetine (FX), a selective serotoninreuptake inhibitor, is prescribed during pregnancy. In adults, FX alters sleep patterns with single doses decreasing total sleep time and rapid eye movement sleep. The effects of FX on sleep in the fetus are unknown. However, 5-hydroxytryptophan, the precursor of serotonin, has been reported to prolong high-voltage (HV) electrocortical (ECoG) activity and increase the incidence of fetal breathing movements (FBM) in the sheep fetus. We hypothesize that FX exposure will decrease the incidence of LV ECoG in the fetus. Twenty-one pregnant sheep were surgically prepared for chronic study of blood gases, ECoG activity, eye movements and FBM. After 3 days of recovery, ewesreceived a 70-mg bolus i.v. infusion of FX or sterile water followed by continuous infusion at a rate of 0.036 mg/min for 8 days. The incidence of low-voltage (LV) ECoG decreased from 54 +/-4% on the preinfusion day to 45 +/-5% on infusion day I in the FX group and remained decreased throughout theinfusion period. In addition, the incidence of both eye movements and FBM was decreased on infusion day I compared to preinfusion day in the FX group. HV ECoG increased from 39 +/-3% on preinfusion day to 68 +/- 14% on FX infusion day I and remained elevated throughout the infusion period. These data show that maternal FX administration alters fetal behavioural state. (C)2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:49:20