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Titolo:
The adhesion molecule TAG-1 mediates the migration of cortical interneurons from the ganglionic eminence along the corticofugal fiber system
Autore:
Denaxa, M; Chan, CH; Schachner, M; Parnavelas, JG; Karagogeos, D;
Indirizzi:
Univ Crete, Sch Med, Dept Basic Sci, Iraklion, Greece Univ Crete Iraklion Greece e, Sch Med, Dept Basic Sci, Iraklion, Greece Inst Mol Biol & Biotechnol, Iraklion, Greece Inst Mol Biol & Biotechnol Iraklion Greece Biotechnol, Iraklion, Greece Univ Coll London, Dept Anat & Dev Biol, London WC1E 6BT, England Univ CollLondon London England WC1E 6BT Biol, London WC1E 6BT, England Univ Hamburg, Zentrum Mol Neurobiol, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 Neurobiol, D-20246 Hamburg, Germany
Titolo Testata:
DEVELOPMENT
fascicolo: 22, volume: 128, anno: 2001,
pagine: 4635 - 4644
SICI:
0950-1991(200111)128:22<4635:TAMTMT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
AXONAL GLYCOPROTEIN TAG-1; NERVOUS-SYSTEM; NEURITE OUTGROWTH; CELL-MIGRATION; IMMUNOGLOBULIN SUPERFAMILY; THALAMOCORTICAL PATHWAY; NEURONAL MIGRATION; CEREBRAL-CORTEX; DLX GENES; GUIDANCE;
Keywords:
GABAergic interneurons; tangential migration; corticofugal fibers; neocortex; immunoglobulin superfamily; adhesion molecules; TAG-1; L1; rat; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Karagogeos, D Univ Crete, Sch Med, Dept Basic Sci, POB 1527, Iraklion, Greece Univ Crete POB 1527 Iraklion Greece 1527, Iraklion, Greece
Citazione:
M. Denaxa et al., "The adhesion molecule TAG-1 mediates the migration of cortical interneurons from the ganglionic eminence along the corticofugal fiber system", DEVELOPMENT, 128(22), 2001, pp. 4635-4644

Abstract

Cortical nonpyramidal cells, the GABA-containing interneurons, originate mostly in the medial ganglionic eminence of the ventral telencephalon and follow tangential migratory routes to reach the dorsal telencephalon. Although several genes that play a role in this migration have been identified, the underlying cellular and molecular cues are not fully understood. We provide evidence that the neural cell adhesion molecule TAG-1 mediates the migration of cortical interneurons. We show that the migration of these neurons occurs along the TAG-1-expressing axons of the developing corticofugal system. The spatial and temporal pattern of expression of TAG-1 on corticofugalfibers coincides with the order of appearance of GABAergic cells in the developing cortex. Blocking the function of TAG-1, but not of L1, another adhesion molecule and binding partner of TAG-1, results in a marked reduction of GABAergic neurons in the cortex. These observations reveal a mechanism by which the adhesion molecule TAG-1, known to be involved in axonal pathfinding, also takes part in neuronal migration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:58:48