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Titolo:
Propagating chemoattractant waves coordinate periodic cell movement in Dictyostelium slugs
Autore:
Dormann, D; Weijer, CJ;
Indirizzi:
Univ Dundee, Sch Life Sci, Div Cell & Dev Biol, Wellcome Trust Bioctr, Dundee DD1 5EH, Scotland Univ Dundee Dundee Scotland DD1 5EH ust Bioctr, Dundee DD1 5EH, Scotland
Titolo Testata:
DEVELOPMENT
fascicolo: 22, volume: 128, anno: 2001,
pagine: 4535 - 4543
SICI:
0950-1991(200111)128:22<4535:PCWCPC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
3-DIMENSIONAL SCROLL WAVES; SLIME-MOLDS; CYCLIC-AMP; DISCOIDEUM; CAMP; MORPHOGENESIS; RECEPTORS; CULMINATION; MUTANTS; AGGREGATION;
Keywords:
cAMP signalling; wave propagation; chemotaxis; cell movement; morphogenesis; Dictyostelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Weijer, CJ Univ Dundee, Sch Life Sci, Div Cell & Dev Biol, Wellcome Trust Bioctr, Dundee DD1 5EH, Scotland Univ Dundee Dundee Scotland DD1 5EH Dundee DD1 5EH, Scotland
Citazione:
D. Dormann e C.J. Weijer, "Propagating chemoattractant waves coordinate periodic cell movement in Dictyostelium slugs", DEVELOPMENT, 128(22), 2001, pp. 4535-4543

Abstract

Migration and behaviour of Dictyostelium slugs results from coordinated movement of its constituent cells. It has been proposed that cell movement iscontrolled by propagating waves of cAMP as during aggregation and in the mound. We report the existence of optical density waves in slugs; they are initiated in the tip and propagate backwards. The waves reflect periodic cell movement and are mediated by cAMP, as injection of cAMP or cAMP phosphodiesterase disrupts wave propagation and results in effects on cell movement and, therefore, slug migration. Inhibiting the function of the cAMP receptor cAR1 blocks wave propagation, showing that the signal is mediated by cAR1. Wave initiation is strictly dependent on the tip; in decapitated slugs nonew waves are initiated and slug movement stops until a new tip regenerates. Isolated tips continue to migrate while producing waves. We conclude from these observations that the tip acts as a pacemaker for cAMP waves that coordinate cell movement in slugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:29:05