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Titolo:
Pulsatile drug-delivery systems
Autore:
Bussemer, T; Otto, I; Bodmeier, R;
Indirizzi:
Free Univ Berlin, Coll Pharm, D-12169 Berlin, Germany Free Univ Berlin Berlin Germany D-12169 l Pharm, D-12169 Berlin, Germany
Titolo Testata:
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
fascicolo: 5, volume: 18, anno: 2001,
pagine: 433 - 458
SICI:
0743-4863(2001)18:5<433:PDS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED-RELEASE PREPARATIONS; INFLAMMATORY BOWEL-DISEASE; ACTIVE ULCERATIVE-COLITIS; PH-DEPENDENT POLYMERS; IN-VITRO EVALUATION; ORAL DOSAGE FORM; GASTROINTESTINAL-TRACT; AZO POLYMERS; BEAGLE DOGS; ORGANIC-ACID;
Keywords:
pulsatile drug-delivery systems; oral drug delivery;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Bodmeier, R Free Univ Berlin, Coll Pharm, Kelchstr 31, D-12169 Berlin, Germany Free Univ Berlin Kelchstr 31 Berlin Germany D-12169 , Germany
Citazione:
T. Bussemer et al., "Pulsatile drug-delivery systems", CR R THER, 18(5), 2001, pp. 433-458

Abstract

Delivery systems with a pulsatile-release pattern are receiving increasinginterest for the development of drugs for which conventional controlled drug-release systems with a continuous release are not ideal. These drugs often have a high first-pass effect or special chronopharmacological needs. A pulsatile-release profile is characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Pulsatile drug-delivery systems can be classified into site-specific systems in which the drug is released at the desired site within the intestinal tract (e.g., the colon), or time-controlled devices in which the drug is released after a well-defined time period. Site-controlled release is usually controlled by environmental factors, Eke the pH or enzymes present in the intestinal tract, whereas the drug release from time-controlled systems is controlled primarily by the delivery system and, ideally, not by the environment. This review covers various single- and multiple-unit oral pulsatile drug-delivery systems with an emphasis on time-controlled drug-release systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 01:19:31