Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Gender-related plasma levels of progesterone, interleukin-8 and interleukin-10 during and after cardiopulmonary bypass in infants and children
Autore:
Trotter, A; Muck, K; Grill, HJ; Schirmer, U; Hannekum, A; Lang, D;
Indirizzi:
Univ Ulm, Childrens Hosp, Pediat Cardiol Sect, Ulm, Germany Univ Ulm UlmGermany Childrens Hosp, Pediat Cardiol Sect, Ulm, Germany Univ Ulm, Dept Obstet & Gynecol, Ulm, Germany Univ Ulm Ulm GermanyUniv Ulm, Dept Obstet & Gynecol, Ulm, Germany Univ Ulm, Dept Cardiac Anesthesia, Ulm, Germany Univ Ulm Ulm GermanyUniv Ulm, Dept Cardiac Anesthesia, Ulm, Germany Univ Ulm, Dept Cardiac Surg, Ulm, Germany Univ Ulm Ulm GermanyUniv Ulm, Dept Cardiac Surg, Ulm, Germany
Titolo Testata:
CRITICAL CARE
fascicolo: 6, volume: 5, anno: 2001,
pagine: 343 - 348
SICI:
1466-609X(2001)5:6<343:GPLOPI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONES; FAILURE; SEPSIS;
Keywords:
bypass; children; gender; infants; interleukin; progesterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Trotter, A Univ Ulm, Childrens Hosp, Pediat Cardiol Sect, Ulm, Germany Univ Ulm Ulm Germany Hosp, Pediat Cardiol Sect, Ulm, Germany
Citazione:
A. Trotter et al., "Gender-related plasma levels of progesterone, interleukin-8 and interleukin-10 during and after cardiopulmonary bypass in infants and children", CRIT CARE, 5(6), 2001, pp. 343-348

Abstract

Background It is known that proinflammatory and anti-inflammatory cytokines are released during and after cardiopulmonary bypass (CPB) in infants andchildren. Sex steroids are known to have immunomodulatory functions, and release of the anti-inflammatory cytokine IL-10 is stimulated by progesterone in vitro. The purpose of the present study was to investigate the plasma levels of progesterone, IL-8 (proinflammatory cytokine) and IL-10, and to relate them to sex and postoperative morbidity. Method Eighteen infants and children (eight female) undergoing CPB were prospectively studied. Plasma levels of progesterone, IL-8 and IL-10 were determined before and 10 min after the start of CPB, and immediately after CPB; and 6 h, 24 h, 3 days and 7 days postoperatively. Organ dysfunction was identified on the basis of arbitrarily defined criteria. Results After CPB, all patients showed significant increases in plasma levels of progesterone, IL-8 and IL-10. Plasma levels of IL-10 were significantly higher in female patients, except for during the immediate postoperative period. According to the criteria used, six out of 10 male patients, but none of the female patients developed multiple organ dysfunction (MOD). Conclusion The present study shows that CPB induces a significant and marked increase in plasma levels of progesterone in infants and children. Studies of administration of progesterone-blocking substances to male and femaleanimals may help to elucidate the roles of sex and progesterone in the setting of CBP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:07:37