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Titolo:
Systemic inflammatory response to cardiac surgery: does female sex really protect?
Autore:
Seghaye, MC; Qing, M; von Bernuth, G;
Indirizzi:
German Heart Ctr, Dept Paediat Cardiol & Congenital Heart Dis, D-8000 Munich, Germany German Heart Ctr Munich Germany D-8000 Heart Dis, D-8000 Munich, Germany Rhein Westfal TH Aachen, Dept Paediat Cardiol, Aachen, Germany Rhein Westfal TH Aachen Aachen Germany Paediat Cardiol, Aachen, Germany
Titolo Testata:
CRITICAL CARE
fascicolo: 6, volume: 5, anno: 2001,
pagine: 280 - 282
SICI:
1466-609X(2001)5:6<280:SIRTCS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOPULMONARY BYPASS; CHILDREN; FAILURE;
Keywords:
cardiac surgery; children; cytokines; sex; inflammation; outcome;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Seghaye, MC German Heart Ctr, Dept Paediat Cardiol & Congenital Heart Dis,D-8000 Munich, Germany German Heart Ctr Munich Germany D-8000 -8000 Munich, Germany
Citazione:
M.C. Seghaye et al., "Systemic inflammatory response to cardiac surgery: does female sex really protect?", CRIT CARE, 5(6), 2001, pp. 280-282

Abstract

Sex hormones have important interactions with the immune system and modulate the inflammatory response. In this regard, oestrogen inhibits the transcription of proinflammatory cytokines and confers tissue protection in experimental models. On the basis of this evidence, Trotter et al. in this issueof Critical Care addressed the question of whether, in children, female sex would protect against the deleterious effects of cardiac operations with cardiopulmonary bypass by providing a favourable antiinflammatory cytokine balance. The observations made in that study suggest sex-related immunomodulation and organ protection during cardiac surgery in the paediatric population. Prospective trials conducted in large series, including sex hormone determination in neonates, infants and children with congenital cardiac defects, are necessary to test this hypothesis. The verification of sex-relatedintraoperative organ protection would provide new opportunities for preventing the uncontrolled systemic inflammatory response that may occur during cardiac surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:07:39