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Titolo:
Comparison of airway conductance and FEV1 as measures of airway responsiveness to methacholine - Discrimination of small differences in bronchial responsiveness with Gaw and FEV1
Autore:
Sundblad, BM; Malmberg, P; Larsson, K;
Indirizzi:
Natl Inst Working Life, Programme Res Hlth & Climate, S-11279 Stockholm, Sweden Natl Inst Working Life Stockholm Sweden S-11279 -11279 Stockholm, Sweden
Titolo Testata:
CLINICAL PHYSIOLOGY
fascicolo: 6, volume: 21, anno: 2001,
pagine: 673 - 681
SICI:
0144-5979(200111)21:6<673:COACAF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-FUNCTION TESTS; DOSE-RESPONSE CURVES; HEALTHY-SUBJECTS; INTERRUPTER TECHNIQUE; PROVOCATION TESTS; REFERENCE VALUES; RESPIRATORY RESISTANCE; REGRESSION EQUATIONS; SMOKING VARIABLES; HISTAMINE;
Keywords:
atopy; methacholine; occupational exposure; provocation test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Sundblad, BM Natl Inst Working Life, Programme Res Hlth & Climate, S-11279Stockholm, Sweden Natl Inst Working Life Stockholm Sweden S-11279 olm, Sweden
Citazione:
B.M. Sundblad et al., "Comparison of airway conductance and FEV1 as measures of airway responsiveness to methacholine - Discrimination of small differences in bronchial responsiveness with Gaw and FEV1", CLIN PHYSL, 21(6), 2001, pp. 673-681

Abstract

When defining bronchial responsiveness in healthy, non-asthmatic, subjectsexposed in different working situations, it is not clear whether differentoutcome measures yield similar results. Therefore, the concentration and dose of methacholine that caused a 20% decrease in forced expiratory volume in 1 s (FEV1) (PC20(FEV1) and PD20(FEV1)), the corresponding change in Gaw and the relationship between the dose-response slope (DRS) for FEV1 and Gawwas studied in different working populations and healthy control subjects (n = 1038). The two outcome measures were compared in groups of subjects inwhom differences in bronchial responsiveness could be anticipated [atopics(n = 72) and non-atopics (n = 207) and subjects exposed (n = 54) and not exposed (n = 32) to saw dust]. A bronchial challenge was also made before and after exposure in a swine confinement building, an exposure known to increase bronchial responsiveness (n = 37). PD20(FEV1) was 1.7 mg in atopics and 4.9 mg in non-atopics, 7.1 mg in saw dust exposed and >20 mg in non-exposed subjects and 5.3 mg before and 0.79 mg after exposure to organic dust. There was a correlation between DRSFEV1, and DRSGaw, r = 0.87 (P<0.001). In subjects who were highly sensitive to methacholine a 20% change in FEV1 corresponded to <40% change in Gaw, while a 20% decrease in FEV1 corresponded to none or a minor decrease in Gaw in subjects with less methacholine-sensitive airways. The ability to detect differences in bronchial responsivenessbetween groups, or to detect changes in bronchial responsiveness followingexposure was approximately the same for FEV1 and Gaw. The reproducibility was similar for both variables and a second measurement was within one doubling of the methacholine concentration of the first provocation in approximate to 95% of all measurements (n = 41). In conclusion, with our methacholine provocation method, FEV1 and Gaw had similar sensitivity in detecting small differences in bronchial responsiveness in healthy subjects.

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Documento generato il 29/03/20 alle ore 23:43:26