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Titolo:
Intravenous magnesium sulfate does not increase ventricular CSF ionized magnesium concentration of patients with intracranial hypertension
Autore:
Brewer, RP; Parra, A; Borel, CO; Hopkins, MB; Reynolds, JD;
Indirizzi:
Duke Univ, Med Ctr, Dept Anesthesiol, Div Womens Anesthesia, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Div Womens Anesthesia, Durham, NC 27710 USA
Titolo Testata:
CLINICAL NEUROPHARMACOLOGY
fascicolo: 6, volume: 24, anno: 2001,
pagine: 341 - 345
SICI:
0362-5664(200111/12)24:6<341:IMSDNI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEIZURES; PLASMA; STROKE; BRAIN;
Keywords:
cerebrospinal fluid; intracranial hypertension; magnesium;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Reynolds, JD Duke Univ, Med Ctr, Dept Anesthesiol, Div Womens Anesthesia, Box 3094, Durham, NC 27710 USA Duke Univ Box 3094 Durham NC USA 27710 , Durham, NC 27710 USA
Citazione:
R.P. Brewer et al., "Intravenous magnesium sulfate does not increase ventricular CSF ionized magnesium concentration of patients with intracranial hypertension", CLIN NEUROP, 24(6), 2001, pp. 341-345

Abstract

Magnesium sulfate has attracted interest as a potential neuroprotectant but passage of magnesium ion into the central nervous system has not been well documented. For this study, we quantified plasma and cerebrospinal fluid (CSF) ionized magnesium concentration after systemic magnesium sulfate infusion in patients with intracranial hypertension, Patients (N = 9) received an intravenous infusion of 5 g/20 mmol magnesium sulfate (125 mL of a 4% wt/vol solution) over 30 minutes. Before and after dosing, CSF (from an indwelling ventricular catheter) and blood samples were collected at hourly intervals. Ionized magnesium concentration in all samples was determined using an electrolyte analyzer. Baseline plasma and CSF ionized magnesium concentrations were 0.58 +/- 0.05 and 0.82 +/- 0.06 mmol/L, respectively. Intravenous magnesium sulfate infusion significantly increased plasma ionized magnesium concentration (peak, 0.89 +/- 0.11 mmol/L), but CSF magnesium levels did not change during the 4-hour study. Systemic administration of magnesium sulfate failed to increase CSF ionized magnesium concentration in patients With intracranial hypertension despite increasing plasma magnesium levels by > 50%.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:14:04