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Titolo:
Focal neurological disease in patients with acquired immunodeficiency syndrome
Autore:
Skiest, DJ;
Indirizzi:
Univ Texas, SW Med Ctr, Div Infect Dis, Dept Internal Med, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 s, Dept Internal Med, Dallas, TX 75390 USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 1, volume: 34, anno: 2002,
pagine: 103 - 115
SICI:
1058-4838(20020101)34:1<103:FNDIPW>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; CENTRAL-NERVOUS-SYSTEM; ACTIVE ANTIRETROVIRAL THERAPY; HIV-INFECTED PATIENTS; POLYMERASE CHAIN-REACTION; STEREOTAXIC BRAIN BIOPSY; EMISSION COMPUTED-TOMOGRAPHY; IMMUNE-DEFICIENCY-SYNDROME; CEREBROSPINAL-FLUID ANALYSIS; JC VIRUS LOAD;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
154
Recensione:
Indirizzi per estratti:
Indirizzo: Skiest, DJ Univ Texas, SW Med Ctr, Div Infect Dis, Dept Internal Med, 5323Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 75390 USA
Citazione:
D.J. Skiest, "Focal neurological disease in patients with acquired immunodeficiency syndrome", CLIN INF D, 34(1), 2002, pp. 103-115

Abstract

Focal neurological disease in patients with acquired immunodeficiency syndrome may be caused by various opportunistic pathogens and malignancies, including Toxoplasma gondii, progressive multifocal leukoencephalopathy (PML),cytomegalovirus (CMV), and Epstein-Barr virus-related primary central nervous system (CNS) lymphoma. Diagnosis may be difficult, because the findingsof lumbar puncture, computed tomography (CT), and magnetic resonance imaging are relatively nonspecific. Newer techniques have led to improved diagnostic accuracy of these conditions. Polymerase chain reaction (PCR) of cerebrospinal fluid specimens is useful for diagnosis of PML, CNS lymphoma, and CMV encephalitis. Recent studies have indicated the diagnostic utility of new neuroimaging techniques, such as single-photon emission CT and positron emission tomography. The combination of PCR and neuroimaging techniques mayobviate the need for brain biopsy in selected cases. However, stereotacticbrain biopsy, which is associated with relatively low morbidity rates, remains the reference standard for diagnosis. Highly active antiretroviral therapy has improved the prognosis of several focal CNS processes, most notably toxoplasmosis, PML, and CMV encephalitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:36:13