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Titolo:
Effects of rapid atrial pacing on the arrhythmogenic activity of single cardiomyocytes from pulmonary veins - Implication in initiation of atrial fibrillation
Autore:
Chen, YJ; Chen, SA; Chen, YC; Yeh, HL; Chan, P; Chang, MS; Lin, CI;
Indirizzi:
Natl Def Med Ctr, Inst Pharmacol, Taipei 114, Taiwan Natl Def Med Ctr Taipei Taiwan 114 r, Inst Pharmacol, Taipei 114, Taiwan Natl Def Med Ctr, Dept Biomed Engn, Taipei 114, Taiwan Natl Def Med Ctr Taipei Taiwan 114 Dept Biomed Engn, Taipei 114, Taiwan Natl Yang Ming Univ, Vet Gen Hosp, Sch Med, Dept Med, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Med, Dept Med, Taipei 112, Taiwan Natl Yang Ming Univ, Vet Gen Hosp, Sch Med, Inst Clin Med,Cardiovasc Res Ctr, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 iovasc Res Ctr, Taipei 112, Taiwan Wan Fang Hosp, Taipei, Taiwan Wan Fang Hosp Taipei TaiwanWan Fang Hosp, Taipei, Taiwan Mackay Mem Hosp, Taipei, Taiwan Mackay Mem Hosp Taipei TaiwanMackay Mem Hosp, Taipei, Taiwan
Titolo Testata:
CIRCULATION
fascicolo: 23, volume: 104, anno: 2001,
pagine: 2849 - 2854
SICI:
0009-7322(200112)104:23<2849:EORAPO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED INWARD CURRENT; ELECTROPHYSIOLOGICAL CHARACTERISTICS; ATRIOVENTRICULAR NODE; IONIC MECHANISMS; CELLS; RABBIT; POTASSIUM; MYOCYTES; MUSCLE; HUMANS;
Keywords:
action potentials; fibrillation; ion channels; pacing; lung; veins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, CI Natl Def Med Ctr, Inst Pharmacol, 161,Minchuan E Rd,Sec 6,Neihu, Taipei 114, Taiwan Natl Def Med Ctr 161,Minchuan E Rd,Sec 6,Neihu Taipei Taiwan 114
Citazione:
Y.J. Chen et al., "Effects of rapid atrial pacing on the arrhythmogenic activity of single cardiomyocytes from pulmonary veins - Implication in initiation of atrial fibrillation", CIRCULATION, 104(23), 2001, pp. 2849-2854

Abstract

Background-Pulmonary veins (PVs) are important sources of paroxysmal atrial fibrillation. Long-term rapid atrial pacing (RAP) changes atrial electrophysiology and facilitates the maintenance of atrial fibrillation. It is notclear whether RAP alters the arrhythmogenic activity of PVs. The purpose of this study was to isolate single PV cardiomyocytes from control and RAP dogs and evaluate their electrophysiological. characteristics. Methods and Results-The action potential and ionic currents were investigated in PV cardiomyocytes from control and long-term (6 to 8 weeks) RAP (780bpm) dogs by use of the whole-cell clamp technique. Dissociation of PVs yielded rod-shaped single cardiomyocytes without (n=91, 60%) or with (n=60, 40%) pacemaker activity. Compared with the control group, the RAP dog PV cardiomyocytes had faster beating rates (0.86 +/-0.28 versus 0.45 +/-0.07 Hz, P <0.05) and shorter action potential duration. The RAP dog PV cardiomyocytes with pacemaker activity have a higher incidence of delayed (59% versus 7%, P <0.001) or early (24% versus 0%, P <0.005) afterdepolarization. The RAP dog PV cardiomyocytes with pacemaker activity had smaller slow inward andtransient outward but larger transient inward (0.017 +/-0.004 versus 0.009+/-0.002 pA/pF, P <0.05) and pacemaker (0.111 +/-0.019 versus 0.028 +/-0.008 pA/pF, P <0.001) currents. The RAP dog PV cardiomyocytes without pacemaker activity had only smaller slow inward and transient outward and larger pacemaker currents. Conclusions-PVs contain multiple cardiomyocytes with distinct electrophysiological characteristics. RAP changes the electrophysiological characteristics and arrhythmogenic activity of PVs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 09:54:16