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Titolo:
Cisplatin-induced vomiting depends on circadian timing
Autore:
Kobayashi, M; To, H; Tokue, A; Fujimura, A; Kobayashi, E;
Indirizzi:
Jichi Med Sch, Ctr Mol Med, Dept Urol, Minami Kawachi, Tochigi, Japan Jichi Med Sch Minami Kawachi Tochigi Japan inami Kawachi, Tochigi, Japan Jichi Med Sch, Ctr Mol Med, Div Organ Replacement Res, Minami Kawachi, Tochigi, Japan Jichi Med Sch Minami Kawachi Tochigi Japan inami Kawachi, Tochigi, Japan
Titolo Testata:
CHRONOBIOLOGY INTERNATIONAL
fascicolo: 5, volume: 18, anno: 2001,
pagine: 851 - 863
SICI:
0742-0528(2001)18:5<851:CVDOCT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
M-RECEPTOR ANTAGONISM; CANCER-CHEMOTHERAPY; FUROSEMIDE DIURESIS; RATS; TOXICITY; MANNITOL; CIS-DICHLORODIAMMINEPLATINUM(II); THERAPY;
Keywords:
chronotherapy; cisplatin and furosemide; vomiting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, M Dorn Med Ctr, Dept Dev Biol & Anat, Res 151,6439 Garners Ferry Rd, Columbia, SC 29209 USA Dorn Med Ctr Res 151,6439 Garners Ferry Rd Columbia SC USA 29209
Citazione:
M. Kobayashi et al., "Cisplatin-induced vomiting depends on circadian timing", CHRONOBIO I, 18(5), 2001, pp. 851-863

Abstract

We examined whether the clock time of cisplatin plus antiemetic and diuretic administration affects the amount of cisplatin-associated emesis and severity of renal toxicity. We treated 22 patients with urogenital cancer withtwo courses of chemotherapy containing 70 mg/m(2) of cisplatin. Cisplatin together with furosemide was administered in the morning (05:00) or evening(17:00) during two courses I month apart in a crossover fashion. Ondansetron was given either before or after cisplatin to control nausea and vomiting. The number of vomiting episodes, serum creatinine, serum urea nitrogen (BUN), creatinine clearance, and urinary beta -N-acetyl glucosamidase (NAG) concentration were evaluated before and after each treatment course. Regardless of the timing of ondansetron, morning compared to evening cisplatin was always associated with greater vomiting in the first treatment course. However, prophylactic administration of ondansetron markedly diminished the impact of the clock time of cisplatin administration. Serum creatinine transiently decreased rather than increased 14 days after cisplatin and furosemide administration, while NAG excretion increased 3 days after cisplatin andfurosemide administration. In the first course, serum creatinine levels were similar regardless of the clock time of cisplatin and furosemide administration. However, in the second course, serum creatinine rose in patients given evening cisplatin and furosemide, while it remained unchanged in thosegiven morning cisplatin and furosemide. Moreover, the first course morningcisplatin and furosemide treatment was associated with less change in NAG excretion (less kidney toxicity) than the first course of evening cisplatinand furosemide treatment. The second course evening cisplatin and furosemide treatment was associated with an increase in NAG excretion compared to the first course of treatment, while morning cisplatin and furosemide treatment in the second course showed less change in NAG excretion compared to the first course. The clock time of cisplatin administration had an impact onthe frequency of emesis. Prophylactic ondansetron, however, diminished thetime-of-day dependency of cisplatin-induced vomiting. Administration of cisplatin and furosemide in the morning rather than evening appears to cause less renal damage, and this damage may be further reduced with aggressive hydration and routine administration of furosemide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 11:12:58