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Titolo:
Natural coagulation inhibitor proteins in young patients with cerebral ischemia
Autore:
Olah, L; Misz, M; Kappelmayer, J; Ajzner, E; Csepany, T; Fekete, I; Bereczki, D; Blasko, G; Csiba, L;
Indirizzi:
Debrecen Univ Med, Fac Med, Dept Neurol, H-4012 Debrecen, Hungary DebrecenUniv Med Debrecen Hungary H-4012 urol, H-4012 Debrecen, Hungary Debrecen Univ Med, Fac Med, Dept Clin Biochem & Mol Pathol, H-4012 Debrecen, Hungary Debrecen Univ Med Debrecen Hungary H-4012 thol, H-4012 Debrecen, Hungary Chinoin Ltd, Budapest, Hungary Chinoin Ltd Budapest HungaryChinoin Ltd, Budapest, Hungary
Titolo Testata:
CEREBROVASCULAR DISEASES
fascicolo: 4, volume: 12, anno: 2001,
pagine: 291 - 297
SICI:
1015-9770(2001)12:4<291:NCIPIY>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR-1; POOR ANTICOAGULANT RESPONSE; FACTOR-V-LEIDEN; VENOUS THROMBOSIS; CEREBROVASCULAR-DISEASE; PROTHROMBIN GENE; S DEFICIENCY; 3'-UNTRANSLATED REGION; MYOCARDIAL-INFARCTION; ABNORMAL PLASMINOGEN;
Keywords:
young patients; cerebral ischemia; thrombophilia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Csiba, L Debrecen Univ Med, Fac Med, Dept Neurol, Nagyerdei Krt 98, H-4012Debrecen, Hungary Debrecen Univ Med Nagyerdei Krt 98 Debrecen Hungary H-4012 ngary
Citazione:
L. Olah et al., "Natural coagulation inhibitor proteins in young patients with cerebral ischemia", CEREB DIS, 12(4), 2001, pp. 291-297

Abstract

Disturbances of coagulation and fibrinolytic pathways were studied in 53 young patients with cerebral ischemia. Upon admission 26 of 53 patients had abnormality in at least one of the antithrombin-III, protein C, protein S activities or in activated protein C (APC) ratios. Three months after the first examination the majority of the previously detected abnormalities returned to normal values and the most frequent alterations were decrease in protein S activity (3 patients) and APC resistance (3 patients). Conditions resulting in impaired fibrinolysis were frequently detected upon admission. Elevation of plasminogen activator inhibitor-1, lipoprotein (a), and alpha-2-antiplasmin was present in 23, 10, and 4 cases, respectively. It is concluded that abnormalities of coagulation as well as of the fibrinolytic systems are prevalent in the acute phase of cerebral ischemia, however, the results may be significantly influenced by the disease process or the acute phase effect. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:51:43