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Titolo:
Immune therapy in inflammatory bowel disease and models of colitis
Autore:
Singh, B; Powrie, F; Mortensen, NJM;
Indirizzi:
John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Surg, Oxford OX3 9DU, England John Radcliffe Hosp, Dept Colorectal Surg, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Surg, Oxford OX3 9DU, England Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England Univ Oxford Oxford England OX1 3RE n Sch Pathol, Oxford OX1 3RE, England
Titolo Testata:
BRITISH JOURNAL OF SURGERY
fascicolo: 12, volume: 88, anno: 2001,
pagine: 1558 - 1569
SICI:
0007-1323(200112)88:12<1558:ITIIBD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CD4(+) T-CELLS; CHRONIC INTESTINAL INFLAMMATION; ACTIVE CROHNS-DISEASE; RECOMBINANT HUMAN INTERLEUKIN-10; PLACEBO-CONTROLLED TRIAL; MONOCLONAL-ANTIBODY CA2; RECEPTOR BETA-2 CHAIN; HAPTEN-INDUCED MODEL; GENE-DEFICIENT MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
111
Recensione:
Indirizzi per estratti:
Indirizzo: Singh, B John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU ord OX3 9DU, England
Citazione:
B. Singh et al., "Immune therapy in inflammatory bowel disease and models of colitis", BR J SURG, 88(12), 2001, pp. 1558-1569

Abstract

Background: A proliferation of animal models has not only improved our understanding of inflammatory bowel disease, it has also formed the basis of new treatment strategies. Methods: A search was conducted using the National Library, of Medicine for articles discussing immune therapies for inflammatory bowel disease. Thiswas supplemented by, findings from the authors' own laboratory. Results: Nn overview of the different animal models is presented. These models are used to highlight the recent human trials of immune therapies. Potential future therapies are also discussed. Conclusion: Immune therapies have altered the management of patients with inflammatory bowel disease. In future they will influence not only, the indications for surgery but also its timing and outcome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:51:05