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Titolo:
HRT and its effect on normal ageing of the brain and dementia
Autore:
Compton, J; van Amelsvoort, T; Murphy, D;
Indirizzi:
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England
Titolo Testata:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 6, volume: 52, anno: 2001,
pagine: 647 - 653
SICI:
0306-5251(200112)52:6<647:HAIEON>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN REPLACEMENT THERAPY; DENDRITIC SPINE DENSITY; ALZHEIMERS-DISEASE; OLDER WOMEN; COGNITIVE FUNCTION; POSTMENOPAUSAL WOMEN; ESTRADIOL INCREASES; OXIDATIVE STRESS; PYRAMIDAL CELLS; MENSTRUAL-CYCLE;
Keywords:
ageing; Alzheimer's disease; cognitive function; oestrogen;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Compton, J Inst Psychiat, Dept Psychol Med, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF , England
Citazione:
J. Compton et al., "HRT and its effect on normal ageing of the brain and dementia", BR J CL PH, 52(6), 2001, pp. 647-653

Abstract

There are significant gender differences in human brain disease. For example, females are significantly more likely to suffer from Alzheimer's disease (AD) than men (even after correcting for differences in life expectancy),and females on hormone replacement therapy (HRT) are significantly less likely to suffer from Alzheimer's disease than women who do not take HRT. However the neurobiological basis to these differences in clinical brain disease were unknown until relatively recently. In this review we will discuss results of Studies that show; (i) gender differences in human brain disease are most likely to be explained by gender differences in brain development and ageing, (ii) sex steroids have a significant effect on the brain; (iii)sex steroids are crucial to the development and ageing of brain regions affected in age-related brain diseases (for example AD); (iv) sex steroids interact with neuronal networks and chemical systems at many different levels, (v) sex steroids affect cognitive function in elderly women. Thus, the current literature supports, the hypothesis that sex steroids can modulate brain ageing, and this provides a neurobiological explanation for the significantly higher prevalence of AD in females who do not take HRT, and may leadto new treatment approaches for age-related brain disease including AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 16:52:31