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Titolo:
Platelet function during pregnancy: an evaluation using the PFA-100 analyser
Autore:
Vincelot, A; Nathan, N; Collet, D; Mehaddi, Y; Grandchamp, P; Julia, A;
Indirizzi:
CHU Dupuytren, Hematol Serv, Dept Anaesthesia & Intens Care, F-87042 Limoges, France CHU Dupuytren Limoges France F-87042 ntens Care, F-87042 Limoges, France
Titolo Testata:
BRITISH JOURNAL OF ANAESTHESIA
fascicolo: 6, volume: 87, anno: 2001,
pagine: 890 - 893
SICI:
0007-0912(200112)87:6<890:PFDPAE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTION ANALYZER; EPIDURAL-ANESTHESIA; BLEEDING-TIME; PREECLAMPSIA; PARTURIENTS; COUNTS; WOMEN; THROMBOCYTOPENIA; AGGREGATION; ANALGESIA;
Keywords:
pregnancy; blood, platelets; complications, pre-eclampsia; complications, thrombocytopenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Nathan, N CHU Dupuytren, Hematol Serv, Dept Anaesthesia & Intens Care, 2 Ave Martin Luther King, F-87042 Limoges, France CHU Dupuytren 2 Ave Martin Luther King Limoges France F-87042 e
Citazione:
A. Vincelot et al., "Platelet function during pregnancy: an evaluation using the PFA-100 analyser", BR J ANAEST, 87(6), 2001, pp. 890-893

Abstract

In clinical practice, the only tests of platelet function are bleeding time and platelet number. Bleeding time lacks sensitivity and specificity but the PFA-100, an in vitro analyser of platelet function may be of value. This study aimed to evaluate any correlation between platelet number and function using the PFA-100 in pregnant women. During a 21-month period, plateletfunction was evaluated in whole blood as part of the pre-anaesthetic coagulation testing screen with the PFA-100 using collagen and epinephrine (PFA-EPI) or ADP (PFA-ADP) as platelet agonists. Thrombocytopenia was defined asa platelet number less than 150 G litre(-1). The patients were divided into four groups: Group I (n=110) normal pregnancy; Group II (n=38) thrombocytopenia of pregnancy; Group III (n=13) women with pre-eclampsia without thrombocytopenia; Group IV (n=19) women with pre-eclampsia and thrombocytopenia. Results are expressed as mean (SD). Platelet count was not statistically different between Groups II and IV (111.1 (23.1) vs 99.5 (28.0) G litre(-1)). PFA-EPI was statistically increased in Group II (124.0 (26.3) s), Group III (128.3 (17.9) s), and Group IV (143.6 (47.7) s) compared with normal pregnant patients (114.6 (27.3) s, P<0.05, Mann-Whitney U-test). PFA-ADP was statistically increased only in Group II compared with normal pregnant patients (90.5 (18.9) vs 80.2 (11.2) s, P<0.05). PFA values were increased above normal laboratory values in (four of 38) Group II patients and (six of 19) Group IV patients but in no patients in Group III. PFA-ADP results were correlated with platelet count only in Group IV (r=-0.74, P=0.0003). The increased PFA values and the correlation between PFA-ADP and platelet number in hypertensive thrombocytopenic women confirms that platelet function may be decreased in such patients. In patients with pregnancy-induced thrombocytopenia, platelet function may be preserved when the platelet count is as low as 60 G litre(-1).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:21:46