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Titolo:
Genetic modeling of glioma formation in mice
Autore:
Begemann, M; Fuller, GN; Holland, EC;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Dept Surg Neurosurg, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Cell Biol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 c Ctr, Dept Pathol, Houston, TX 77030 USA
Titolo Testata:
BRAIN PATHOLOGY
fascicolo: 1, volume: 12, anno: 2002,
pagine: 117 - 132
SICI:
1015-6305(200201)12:1<117:GMOGFI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; HUMAN-MALIGNANT GLIOMAS; NEURAL STEM-CELLS; MIDDLE T-ANTIGEN; SECONDARY BRAIN-TUMORS; CENTRAL-NERVOUS-SYSTEM; SRC TRANSGENIC MICE; WILD-TYPE P53; EGF RECEPTOR; HUMAN GLIOBLASTOMA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
132
Recensione:
Indirizzi per estratti:
Indirizzo: Holland, EC Mem Sloan Kettering Canc Ctr, Dept Surg Neurosurg, RRL 917B,1275 York Ave,New York, NY 10021 USA Mem Sloan Kettering Canc Ctr RRL 917B,1275 York Ave New York NY USA 10021
Citazione:
M. Begemann et al., "Genetic modeling of glioma formation in mice", BRAIN PATH, 12(1), 2002, pp. 117-132

Abstract

In addition to the histological features that define gliomas, mutations and other alterations in gene expression and signal transduction are classically found in these tumors. Some of these alterations are likely to be the effects of the neoplastic phenotype, while others may be causative agents essential to the etiologic origin of the disease. The determination of whether specific genetic alterations, either individually or in combination, can serve as the etiology of gliomas requires modeling in animals with the fulfillment of Koch's postulates. Animal modeling studies not only provide information on the potential causes of glioma formation, they also identify novel candidate targets for therapy and provide tumor-bearing animals for preclinical trials. Recently, remarkable strides have been made in the generation of mouse models of the diffuse gliomas that provide unparalleled opportunities for advancing our knowledge of the etiology, maintenance, and treatment of this lethal class of tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:19:00