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Titolo:
Insulin-like growth factor binding protein 2: Gene expression microarrays and the hypothesis-generation paradigm
Autore:
Zhang, W; Wang, H; Song, SW; Fuller, GN;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Canc Genom Core Lab,Div Pathol & Lab Med, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 v Pathol & Lab Med, Houston, TX 77030 USA
Titolo Testata:
BRAIN PATHOLOGY
fascicolo: 1, volume: 12, anno: 2002,
pagine: 87 - 94
SICI:
1015-6305(200201)12:1<87:IGFBP2>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; LASER CAPTURE MICRODISSECTION; II IGF-II; HUMAN GLIOBLASTOMAS; SUPPRESSOR GENES; RECEPTOR-BINDING; MESSENGER-RNA; DNA-SEQUENCE; GLIAL TUMORS; SOLID TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, W Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Canc Genom Core Lab,Div Pathol & Lab Med, Box 85,1515 Holcombe Blvd, Houston, TX 77030 USA Univ Texas Box 85,1515 Holcombe Blvd Houston TX USA 77030 030 USA
Citazione:
W. Zhang et al., "Insulin-like growth factor binding protein 2: Gene expression microarrays and the hypothesis-generation paradigm", BRAIN PATH, 12(1), 2002, pp. 87-94

Abstract

A major goal of modern medicine is to identify key genes and their products that are altered in the diseased state and to elucidate the molecular mechanisms underlying disease development, progression, and resistance to therapy. This is a daunting task given the exceptionally high complexity of thehuman genome. The paradigm for research has historically been hypothesis-driven despite the fact that the hypotheses under scrutiny often rest on tenuous subjective grounds or are derived from and dependent on chance observation. The imminent deciphering of the complete human genome, coupled with recent advances in high-throughput bioanalytical technology, has made possible a new paradigm in which data-based hypothesis-generation Is the initial step in the investigative process, followed by hypothesis-testing. Genomicstechnologies are the primary source of the new hypothesis-generating capabilities that are now empowering biomedical researchers. The synergistic Interaction between contemporary genomics technologies and the hypothesis-generation paradigm is well-illustrated by the discovery and subsequent ongoingstudy of the role of insulin-like growth factor binding protein 2 (IGFBP2)in human glioma biology. Using gene expression microarray technology, the IGFBP2 gene was recently found to be highly and differentially overexpressed in the most advanced grade of human glioma, glioblastoma. Based on this discovery, subsequent functional studies were initiated that suggest that IGFBP2 overexpression may contribute to the invasive nature of glioblastoma, and that IGFBP2 may exert its function via a newly identified novel bindingprotein. The IGFBP2 story is but one example of the power and potential ofthe new molecular methodologies that are transforming modern diagnostic and investigative neuropathology.

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Documento generato il 26/01/20 alle ore 10:36:44