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Titolo:
Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas
Autore:
Eberhart, CG; Kratz, JE; Schuster, A; Goldthwaite, P; Cohen, KJ; Perlman, EJ; Burger, PC;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Oncol, Baltimore, MD 21205 USA
Titolo Testata:
BRAIN PATHOLOGY
fascicolo: 1, volume: 12, anno: 2002,
pagine: 36 - 44
SICI:
1015-6305(200201)12:1<36:CGHDAI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMITIVE NEUROECTODERMAL TUMORS; PEDIATRIC BRAIN-TUMORS; CENTRAL-NERVOUS-SYSTEM; MOLECULAR CYTOGENETIC ANALYSIS; ONCOGENE AMPLIFICATION; 17P DELETIONS; ABNORMALITIES; SUPRATENTORIAL; IMBALANCES; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Eberhart, CG Johns Hopkins Univ Hosp, Dept Pathol, 600 N Wolfe St, Baltimore, MD 21287 USA Johns Hopkins Univ Hosp 600 N Wolfe St Baltimore MD USA 21287
Citazione:
C.G. Eberhart et al., "Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas", BRAIN PATH, 12(1), 2002, pp. 36-44

Abstract

We correlate chromosomal changes in medulloblastomas with histologic subtype, reporting the analysis of 33 medulloblastoma specimens by comparative genomic hybridization, and a subset by fluorescence in situ hybridization. Of the 33 tumors, 5 were desmoplastic/nodular, 10 were histologically classic, and 18 were large cell/anaplastic. Chromosomal gains and losses were more common in anaplastic medulloblastomas than in non-anaplastic ones. We identified 4 medulloblastomas with c-myc amplification and 5 medulloblastomas with N-myc amplification; all 9 were of the large cell/anaplastic subtype. Additional regions with high level gains included 2q14-22, 3p23, 5p14-pter,8q24, 9p22-23, 10p12-pter, 12q24, 12p11-12, 17p11-12, and Xp11. The majority of these high level gains occurred in anaplastic cases. We also found loss of chromosome 17p in 7 large cell/anaplastic cases but no nonanaplastic medulloblastomas. Finally, we detected a significantly increased overall number of chromosomal alterations in large cell/anaplastic medulloblastomas (6.8/case) compared to non-anaplastic ones (3.3/case). These findings support an association between myc oncogene amplification, 17p loss, and large cell/anaplastic histology.

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Documento generato il 23/01/20 alle ore 06:32:30