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Titolo:
The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease
Autore:
Aliev, G; Smith, MA; Seyidova, D; Neal, ML; Lamb, BT; Nunomura, A; Gasimov, EK; Vinters, HV; Perry, G; LaManna, JC; Friedland, RP;
Indirizzi:
Case Western Reserve Univ, Sch Med, Ctr Electron Microscopy, Cleveland, OH44106 USA Case Western Reserve Univ Cleveland OH USA 44106 , Cleveland, OH44106 USA Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Anat, Cleveland, OH 44106 USA Case WesternReserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Neurol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Asahikawa Med Coll, Dept Psychiat & Neurol, Asahikawa, Hokkaido 078, JapanAsahikawa Med Coll Asahikawa Hokkaido Japan 078 kawa, Hokkaido 078, Japan Baku Med Univ, Dept Histol & Embryol, Baku, Azerbaijan Baku Med Univ Baku Azerbaijan , Dept Histol & Embryol, Baku, Azerbaijan Univ Calif Los Angeles, Med Ctr, Dept Pathol & Lab Med, Sect Neuropathol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Med Ctr, Inst Brain Res, Los Angeles, CA 90024 USAUniv Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
BRAIN PATHOLOGY
fascicolo: 1, volume: 12, anno: 2002,
pagine: 21 - 35
SICI:
1015-6305(200201)12:1<21:TROOSI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; NITRIC-OXIDE SYNTHASE; THORACIC AORTIC ENDOTHELIUM; CHROMOSOME TRANSGENIC MICE; CORONARY-ARTERY DISEASE; CHOLESTEROL-FED RABBIT; CEREBRAL BLOOD-FLOW; MITOCHONDRIAL-DNA; GROWTH-FACTOR; HYPERCHOLESTEROLEMIC RABBIT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
142
Recensione:
Indirizzi per estratti:
Indirizzo: Aliev, G Case Western Reserve Univ, Sch Med, Ctr Electron Microscopy, 10900 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ 10900 Euclid Ave Cleveland OH USA 44106
Citazione:
G. Aliev et al., "The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease", BRAIN PATH, 12(1), 2002, pp. 21-35

Abstract

Alzheimer's disease (AD) and stroke are two leading causes of age-associated dementia. A rapidly growing body of evidence Indicates that increased oxidative stress from reactive oxygen radicals is associated with the aging process and age-related degenerative disorders such as atherosclerosis, Ischemia/reperfusion, arthritis, stroke, and neurodegenerative diseases. New evidence has also indicated that vascular lesions are a key factor in the development of AD. This Idea is based on a positive correlation between AD andcardiovascular and cerebrovascular diseases such as arterio- and atherosclerosis and ischemia/reperfusion injury. In this review we consider recent evidence supporting the existence of an intimate relationship between oxidative stress and vascular lesions in the pathobiology of AD. We also considerthe opportunities for therapeutic interventions based on the molecular pathways involved with these causal relationships.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:08:29