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Titolo:
Vigabatrin for tuberous sclerosis complex
Autore:
Curatolo, P; Verdecchia, M; Bombardieri, R;
Indirizzi:
Univ Roma Tor Vergata, Dept Neurosci, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 t Neurosci, I-00133 Rome, Italy
Titolo Testata:
BRAIN & DEVELOPMENT
fascicolo: 7, volume: 23, anno: 2001,
pagine: 649 - 653
SICI:
0387-7604(200111)23:7<649:VFTSC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISUAL-FIELD DEFECT; INFANTILE SPASMS; REVERSIBILITY; MODULATION; SEIZURES; CHILDREN; THERAPY;
Keywords:
vigabatrin; tuberous sclerosis; infantile spasms; partial seizures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Curatolo, P Univ Roma Tor Vergata, Dept Neurosci, Via Tor Vergata 135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata 135 Rome Italy I-00133
Citazione:
P. Curatolo et al., "Vigabatrin for tuberous sclerosis complex", BRAIN DEVEL, 23(7), 2001, pp. 649-653

Abstract

Vigabatrin (VGB) was found to be an effective anti-epileptic drug to reduce infantile spasms in about 50% of patients and it has been found most effective in infantile spasms due to tuberous sclerosis (TSC) in which up to 95% of infants had complete cessation of their spasms. VGB was synthesized toenhance inhibitory gamma-aminobutyric acidergic (GABAergic) transmission by elevating GABA levels via irreversible inhibition of GABA transaminase. The mechanism underlying the particular efficacy of VGB in TSC is still unknown. However, its efficacy suggests that epileptogenesis in TSC may be related to an impairment of GABAerggic transmission. VGB should be considered as the first line monotheraphy for the treatment of infantile spasms in infants with confirmed diagnosis of TSC. The efficacy of VGB treatment can be assessed in less than 10 days, but usually a few days treatment with a dose of about 100 mg/kg/day stops infantile spasms. The cessation of the spasms is associated with a marked improvement of behaviour and mental development. Unfortunately, it has become clear that the use of VGB is associated witha late appearance of visual-field defects in up to 50% of patients. Currently the minimum duration and doses of VGB treatment that can produce side effects are unknown. The feasibility of using short treatment periods (2-3 months) should be investigated. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:31:22