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Titolo:
Mechanism of tonic spasms in West syndrome viewed from ictal SPECT findings
Autore:
Haginoya, K; Munakata, M; Yokoyama, H; Kato, R; Tanaka, S; Hirose, M; Ishitobi, M; Kon, K; Yoshihara, Y; Takayanagi, M; Yamazaki, T; Iinuma, K;
Indirizzi:
Tohoku Univ, Sch Med, Dept Pediat, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ, Sch Med, Dept Radiol, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan
Titolo Testata:
BRAIN & DEVELOPMENT
fascicolo: 7, volume: 23, anno: 2001,
pagine: 496 - 501
SICI:
0387-7604(200111)23:7<496:MOTSIW>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; EMISSION COMPUTED-TOMOGRAPHY; INFANTILE SPASMS; BRAIN-STEM; SEIZURES; HYPSARRHYTHMIA; PERFUSION; EPILEPSY;
Keywords:
West syndrome; single photon emission computed tomography tonic spasms; infantile spasms; hypsarrhythmia; letal single photon emission; computed tomography; asymmetric spasms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Haginoya, K Tohoku Univ, Sch Med, Dept Pediat, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 9808574 Japan
Citazione:
K. Haginoya et al., "Mechanism of tonic spasms in West syndrome viewed from ictal SPECT findings", BRAIN DEVEL, 23(7), 2001, pp. 496-501

Abstract

To clarify the pathophysiology of tonic spasms, 21 patients with West syndrome were analyzed using ictal and interictal single photon emission computed tomography (SPECT). We focused on whether ictal perfusion changes were observed in the focal cortical region. Eight of the patients studied showed definite focal cortical ictal hyperperfusion, indicating that there is a unique subset of West syndrome that can be classified as infantile localization-related epilepsy. Of those eight patients, only two showed asymmetric spasms, suggesting that seizure symptomatology in infants gives only limited information on the localization-related nature of epilepsy. Furthermore, the activation of subcortical structures by focal cortical regions might be attributable to the symmetric seizure phenomena. Thirteen patients showed a diffuse pattern in their ictal SPECTs; this probably included patients withdiffuse hyperperfusion and those with no changes. The following have yet to be determined: (1) whether West syndrome is divided into subgroups based on the origin of spasm,, in that some patients have the origin in the cortical hemisphere and some have the origin in structures other than the cortical hemisphere, such as the brain stern; (2) whether differences in ictal SPECT patterns reflect a unique nature of tonic spasms in West syndrome, where tonic spasms appear in clusters and the interval of each spasm is different among each patient. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:12:39