Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neuroradiological assessment of brain structure and function and its implication in the pathogenesis of West syndrome
Autore:
Juhasz, C; Chugani, HT; Muzik, O; Chugani, DC;
Indirizzi:
Wayne State Univ, Detroit Med Ctr, Childrens Hosp Michigan, Sch Med,Dept Pediat, Detroit, MI USA Wayne State Univ Detroit MI USA an, Sch Med,Dept Pediat, Detroit, MI USA Wayne State Univ, Detroit Med Ctr, Childrens Hosp Michigan, Sch Med,Dept Neurol, Detroit, MI USA Wayne State Univ Detroit MI USA an, Sch Med,Dept Neurol, Detroit, MI USA Wayne State Univ, Detroit Med Ctr, Childrens Hosp Michigan, Sch Med,Dept Radiol, Detroit, MI USA Wayne State Univ Detroit MI USA an, Sch Med,Dept Radiol, Detroit, MI USA
Titolo Testata:
BRAIN & DEVELOPMENT
fascicolo: 7, volume: 23, anno: 2001,
pagine: 488 - 495
SICI:
0387-7604(200111)23:7<488:NAOBSA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; TEMPORAL-LOBE EPILEPSY; FOCAL CORTICAL DYSPLASIA; INFANTILE SPASMS; CEREBRAL-CORTEX; SEROTONIN SYNTHESIS; PARTIAL SEIZURES; QUINOLINIC ACID; IN-VIVO; CHILDREN;
Keywords:
positron emission tomography; infantile spasms; cortical dysplasia; glucose hypometabolism; [C-11]flumazenil; alpha[C-11]methyl-L-tryptophan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Chugani, HT Childrens Hosp Michigan, Pediat Neurol PET Ctr, 3901 Beaubien Blvd, Detroit, MI 48201 USA Childrens Hosp Michigan 3901 Beaubien Blvd Detroit MI USA 48201
Citazione:
C. Juhasz et al., "Neuroradiological assessment of brain structure and function and its implication in the pathogenesis of West syndrome", BRAIN DEVEL, 23(7), 2001, pp. 488-495

Abstract

Neuroimaging studies with magnetic resonance imaging (MRI) and positron emission tomography (PET) scanning a have contributed significantly to our understanding of West syndrome. Cortical dysplastic lesions are the most common abnormalities seen with MRI in infants with spasms, but other structurallesions are also detected occasionally. An underlying cortical dysplasia may not be apparent until myelination has advanced in the brain and poor gray-white matter differentiation becomes observable. Many cortical dysplasticlesions can only be detected using PET scanning of glucose metabolism or alpha -aminobutyric acid(A) (GABA(A)) receptor binding. The MRI and PET findings, together,vith neurophysiological observations, strongly suggest that infantile spasms are initiated as cortical epileptic discharges that, during a 'critical' developmental period, may undergo secondary generalization in an age-dependent mechanism to emerge as spasms. The onset of spasms oftencoincides with the functional maturation of cerebral cortex. Based on datafrom glucose metabolism PET scanning as well as electrophysiological and neurochemical findings on infants with spasms, we have postulated that the offending lesion is a focal or diffuse cortical abnormality which, at a critical stage of maturation, causes abnormal functional interactions with brainstem raphe nuclei which project widely throughout the brain. Raphe-cortical projections could mediate the hypsarrhythmic changes seen on EEG. The prominent serotonergic raphe-striatal pathway and descending spinal pathways may be responsible for secondary generalization of the cortical discharges to result in the relatively symmetric spasms. It is likely that additional factors (e.g. genetic) play a role in the manifestation of the age-specific electroclinical features of West syndrome. Recently developed PET tracers can be used to detect epileptogenic brain regions and also to investigate developmental abnormalities of serotonergic (using the tracer alpha[C-11]methyl-L-tryptophan) and GABAergic (using [C-11]flumazenil) neurotransmitter systems. These systems are implicated in epileptogenesis, and their involvement in the pathophysiology of West syndrome can be further addressed by future functional neuroimaging studies. (C) 2001 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:44:38