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Titolo:
Usefulness of combination therapy in hypertensive patients who do not respond to an angiotensin type 1 receptor antagonist alone
Autore:
Lacourciere, Y;
Indirizzi:
Ctr Hosp Univ Quebec, Hypertens Res Unit, Quebec City, PQ G1V 4G2, Canada Ctr Hosp Univ Quebec Quebec City PQ Canada G1V 4G2 ty, PQ G1V 4G2, Canada
Titolo Testata:
BLOOD PRESSURE MONITORING
, volume: 6, anno: 2001, supplemento:, 1
pagine: S23 - S30
SICI:
1359-5237(200111)6:<S23:UOCTIH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DOSE HYDROCHLOROTHIAZIDE; TO-MODERATE HYPERTENSION; PLACEBO-CONTROLLED TRIAL; SINGLE-DRUG THERAPY; BLOOD-PRESSURE; ANTIHYPERTENSIVE AGENTS; DOUBLE-BLIND; TELMISARTAN; POPULATION; PREVALENCE;
Keywords:
telmisartan; hydrochlorothiazide; hypertension; AT(1) receptor antagonist; fixed-dose combination therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Lacourciere, Y Ctr Hosp Univ Quebec, Hypertens Res Unit, 2705 Blvd Laurier,Room S135, Quebec City, PQ G1V 4G2, Canada Ctr Hosp Univ Quebec 2705 Blvd Laurier,Room S135 Quebec City PQ Canada G1V 4G2
Citazione:
Y. Lacourciere, "Usefulness of combination therapy in hypertensive patients who do not respond to an angiotensin type 1 receptor antagonist alone", BL PRESS M, 6, 2001, pp. S23-S30

Abstract

Objective To compare the antihypertensive effects and tolerability of a telmisartan 80 mg + hydrochlorothiazide 12.5 mg fixed-dose combination and telmisartan 80 mg monotherapy in patients with mild-to-moderate essential hypertension that is inadequately controlled by telmisartan alone. Methods After 8 weeks of telmisartan 40-80 mg monotherapy, 491 patients (mean age 55.3 years; 62.9% men) whose seated diastolic blood pressure (DBP) was at least 90 mmHg were allocated randomly to groups to receive once-daily fixed-dose telmisartan 80 mg + hydrochlorothiazide 12.5 mg (n = 246) or telmisartan 80 mg (n = 245). Trough cuff blood pressure (24 h after administration of drug) was measured after 4 and 8 weeks of treatment. Results Telmisartan 80 mg + hydrochlorothiazide 12.5 mg produced additional reductions over telmisartan 80 mg of 5.7 mmHg in seated systolic blood pressure (SBP) and 3.1 mmHg in seated DBP (P < 0.01). Most of the additional effect occurred during the first 4 weeks of treatment. Blood pressure was normalized (SBP less than 140 mmHg and DBP less than 90 mmHg) in a significantly greater proportion of patients receiving the comibination therapy thanamong those receiving the monotherapy (41.5% compared with 26.1%; P < 0.05). Both treatments were well tolerated, and the incidence of adverse eventsduring the double-blind period was similar in the two treatment groups (36.2% for combination therapy and 39.6% for monotherapy). Conclusions A fixed-dose combination of telmisartan 80 mg + hydrochlorothiazide 12.5 mg confers clinically significant additional blood pressure reductions in patients whose hypertension is inadequately controlled by telmisartan alone. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:43:21