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Titolo:
Swelling of mitochondria induced by juvenile hormone in larval salivary glands of Drosophila melanogaster
Autore:
Farkas, R; Sutakova, G;
Indirizzi:
Slovak Acad Sci, Inst Expt Endocrinol, SK-83306 Bratislava, Slovakia Slovak Acad Sci Bratislava Slovakia SK-83306 -83306 Bratislava, Slovakia Slovak Acad Sci, Inst Expt Phytopathol & Entomol, Ivanka Pri Dunaji 90028,Slovakia Slovak Acad Sci Ivanka Pri Dunaji Slovakia 90028 i Dunaji 90028,Slovakia
Titolo Testata:
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
fascicolo: 6, volume: 79, anno: 2001,
pagine: 755 - 764
SICI:
0829-8211(200112)79:6<755:SOMIBJ>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-C-OXIDASE; RAT-LIVER MITOCHONDRIA; CULTURED IN-VITRO; THYROID-HORMONES; OXIDATIVE-PHOSPHORYLATION; GENE-PRODUCT; PRIMARY SITE; AH RECEPTOR; KINASE-C; INDUCTION;
Keywords:
Drosophila; salivary glands; juvenile hormone; uncoupling; mitochondria; oxidative phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Farkas, R Slovak Acad Sci, Inst Expt Endocrinol, Vlarska 3, SK-83306 Bratislava, Slovakia Slovak Acad Sci Vlarska 3 Bratislava Slovakia SK-83306 Slovakia
Citazione:
R. Farkas e G. Sut'akova, "Swelling of mitochondria induced by juvenile hormone in larval salivary glands of Drosophila melanogaster", BIOC CELL B, 79(6), 2001, pp. 755-764

Abstract

Treatment of Drosophila larval salivary glands with juvenile hormone or its analogues leads to ultrastructural changes of mitochondria that mimic those seen after application of uncouplers of oxidative phosphorylation. This alteration of mitochondria, also known as swelling, is manifested in strongdilatation of their intercristae space. The mitochondrial response of salivary glands to juvenile hormone is restricted to collum cells that are known to be ultrastructurally and functionally different from transitional and corpus cells and may reflect their specialization in energy metabolism and water/ion balance. Morphological change of mitochondria and about a fivefold increase in cytochrome c oxidase activity in response to juvenile hormoneappear to be a consequence of uncoupling of oxidative phosphorylation. We have noticed no significant difference of the responses in Methoprene, the juvenile hormone resistant mutant, suggesting that this action of juvenile hormone may be mediated via a mechanism different from that using nuclear transcription factors. The "uncoupling" effect is caused also by juvenile hormone analogues which are considered inactive in producing morphogenetic effects in Drosophila. Mitochondrial response is independent of transcriptionand translation, as revealed by the use of RNA and protein synthesis inhibitors. Given these data together, we reasoned that the protonophoric/uncoupling effect of juvenile hormone is a cell type specific nongenomic responseto this lipophilic ligand and contrasts with widely accepted notions aboutnuclear action of juvenile hormone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:12:31