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Titolo:
Quantitative analysis of papaverine-mediated blood-brain barrier disruption in rats
Autore:
Bhattacharjee, AK; Kondoh, T; Nagashima, T; Ikeda, M; Ehara, K; Tamaki, N;
Indirizzi:
Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 g, Chuo Ku, Kobe, Hyogo 6500017, Japan Hyogo Childrens Hosp, Dept Neurosurg, Suma Ku, Kobe, Hyogo 6540081, Japan Hyogo Childrens Hosp Kobe Hyogo Japan 6540081 Kobe, Hyogo 6540081, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 289, anno: 2001,
pagine: 548 - 552
SICI:
0006-291X(20011130)289:2<548:QAOPBB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL VASOSPASM; SUBARACHNOID HEMORRHAGE; INTRAARTERIAL INFUSION; INHIBITION;
Keywords:
blood-brain barrier; in situ brain perfusion; papaverine; cerebrovascular permeability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Kondoh, T Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, 7-5-1 KusunokiCho, Kobe, Hyogo 6500017, Japan Kobe Univ 7-5-1 Kusunoki Cho Kobe Hyogo Japan 6500017 017, Japan
Citazione:
A.K. Bhattacharjee et al., "Quantitative analysis of papaverine-mediated blood-brain barrier disruption in rats", BIOC BIOP R, 289(2), 2001, pp. 548-552

Abstract

The blood-brain barrier (BBB) is a permeability barrier of interconnected brain capillary endothelial cells. Intraarterial infusion of papaverine relieves cerebral vasospasms by inhibiting smooth muscle contractions and it may simultaneously lead to a disruption of BBB permeability. To date, the mechanism underlying this phenomenon and the quantification of BBB disruptionremains elusive. We first examined the changes in cerebrovascular permeability after an intracarotid infusion of papaverine (0.20%) in rats by an in situ brain perfusion technique. We then demonstrated that changes in cerebrovascular permeability depend on the concentration of papaverine. This is the first study in which the degree of BBB disruption was accurately quantified in terms of [C-14]sucrose and it was demonstrated that papaverine has aprolonged effect on cerebrovascular permeability. This result suggests theimportance of in vivo experiments for a precise evaluation of permeabilityfor many other agents, particularly for the central nervous system. (C) 2001 Elsevier Science.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 20:29:26