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Titolo:
Is the HM story only a 'remote memory'? Some facts about hippocampus and memory in humans
Autore:
Deweer, B; Pillon, B; Pochon, JB; Dubois, B;
Indirizzi:
Hop La Pitie Salpetriere, INSERM, E 007, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 007, F-75013 Paris, France Hop La Pitie Salpetriere, Federat Neurol, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 rol, F-75013 Paris, France
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 127, anno: 2001,
pagine: 209 - 224
SICI:
0166-4328(200112)127:1-2<209:ITHSOA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL TEMPORAL-LOBE; POSITRON EMISSION TOMOGRAPHY; PROGRESSIVE SUPRANUCLEAR PALSY; ALZHEIMERS-DISEASE; EPISODIC MEMORY; PARKINSONS-DISEASE; HUNTINGTONS-DISEASE; VERBAL MEMORY; OLDER ADULTS; SPATIAL LOCATION;
Keywords:
hippocampus; temporal lobe amnesia; Alzheimer's disease; Parkinson's disease; progressive nuclear palsy; Huntington's disease; PET; MRI;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
168
Recensione:
Indirizzi per estratti:
Indirizzo: Deweer, B Hop La Pitie Salpetriere, INSERM, E 007, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 13 Paris, France
Citazione:
B. Deweer et al., "Is the HM story only a 'remote memory'? Some facts about hippocampus and memory in humans", BEH BRA RES, 127(1-2), 2001, pp. 209-224

Abstract

In this review, we argue that a number of current data support the notion that the hippocampal formations play an important role in episodic memory in humans. We will focus on data gathered from three topics within this field: (1) the neuropsychological study of memory in degenerative diseases, which provides striking dissociations of processes, as a function of the location of cerebral lesions and of their functional consequences; (2) the description of patients' memory difficulties after unilateral medial temporal lobectomy. Given the visuo-verbal dissociation, we may anticipate that the study of the effects of such lesions may help in the understanding of the role of the hippocampus in memory, in terms of. (i) the stage of memory processing where the hippocampus is really involved (encoding, consolidation and/or retrieval); (ii) the specificity of the impairments as a function of thenature (verbal vs. visuo-spatial) of the to-be-remembered material; (3) recent evidence from imaging studies: (i) the morphological approach, which provides interesting information with the study of correlations between the volumes of diverse cerebral regions particularly the volume of the hippocampus-and episodic memory performance and other cognitive measures; (ii) metabolic studies, using PET scan, which were first designed for correlational analyses between performance in episodic memory tasks and glucose utilization at rest in diverse regions of interest, such as the hippocampal formations, (iii) activation studies with PET and functional MRI, which are actually more straightforward, since they allow correlations between the metabolism in regions of interest and performance on line (e.g. during encoding or retrieval of information). In our view, inasmuch as such different approaches - degenerative diseases, lesions or imagery-provide convergent information, they give renewed weight to the notion according to which the hippocampal formations are critically concerned in episodic memory processes. (C) 2001 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:20:44