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Titolo:
Stress, memory, and the hippocampus: can't live with it, can't live without it
Autore:
Lupien, SJ; Lepage, M;
Indirizzi:
McGill Univ, Dept Psychiat, Douglas Hosp Res Ctr, Res Ctr, Verdun, PQ H4H 1R3, Canada McGill Univ Verdun PQ Canada H4H 1R3 Res Ctr, Verdun, PQ H4H 1R3, Canada Douglas Hosp, Montreal Geriatr Inst, Lab Human Psychoneuroendocrine Res, Verdun, PQ H4H 1R3, Canada Douglas Hosp Verdun PQ Canada H4H 1R3 ine Res, Verdun, PQ H4H 1R3, Canada
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 127, anno: 2001,
pagine: 137 - 158
SICI:
0166-4328(200112)127:1-2<137:SMATHC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA3 PYRAMIDAL NEURONS; MEDIAL TEMPORAL-LOBE; HUMAN MINERALOCORTICOID RECEPTOR; POSITRON EMISSION TOMOGRAPHY; ADRENAL-STEROID RECEPTORS; LONG-TERM POTENTIATION; CHRONIC CORTICOSTERONE TREATMENT; PITUITARY-ADRENOCORTICAL AXIS; RECURRENT MAJOR DEPRESSION; PRIMED BURST POTENTIATION;
Keywords:
glucocorticoids; hippocampus; memory; brain imaging; human; receptors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
224
Recensione:
Indirizzi per estratti:
Indirizzo: Lupien, SJ McGill Univ, Dept Psychiat, Douglas Hosp Res Ctr, Res Ctr, Verdun, PQ H4H 1R3, Canada McGill Univ Verdun PQ Canada H4H 1R3 erdun, PQ H4H 1R3, Canada
Citazione:
S.J. Lupien e M. Lepage, "Stress, memory, and the hippocampus: can't live with it, can't live without it", BEH BRA RES, 127(1-2), 2001, pp. 137-158

Abstract

Since the 1968s discovery of receptors for stress hormones (corticosteroids) in the rodent hippocampus, a tremendous amount of data has been gatheredon the specific and somewhat isolated role of the hippocampus in stress reactivity. The hippocampal sensitivity to stress has also been extended in order to explain the negative impact of stress and related stress hormones on animal and human cognitive function. As a consequence, a majority of studies now uses the stress-hippocampus link as a working hypothesis in settingup experimental protocols. However, in the last decade, new data were gathered showing that stress impacts on many cortical and subcortical brain structures other than the hippocampus. The goal of this paper is to summarize the four major arguments previously used in order to confirm the stress-hippocampus link, and to describe new data showing the implication of other brain regions for each of these previously used arguments. The conclusion of this analysis will be that scientists should gain from extending the impactof stress hormones to other brain regions, since hormonal functions on thebrain are best explained by their modulatory role on various brain structures, rather than by their unique impact on one particular brain region. (C)2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:30:49