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Titolo:
The hippocampal debate: are we asking the right questions?
Autore:
Redish, AD;
Indirizzi:
Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 urosci, Minneapolis, MN 55455 USA
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 127, anno: 2001,
pagine: 81 - 98
SICI:
0166-4328(200112)127:1-2<81:THDAWA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONFIGURAL ASSOCIATION THEORY; SPATIAL FIRING PATTERNS; MULTIPLE MEMORY-SYSTEMS; AUDITORY WORKING-MEMORY; LONG-TERM POTENTIATION; SINGLE UNIT-ACTIVITY; FREELY-MOVING RAT; IMPAIRED RECOGNITION MEMORY; ENTORHINAL CORTEX LESIONS; CAUDATE-NUCLEUS LESIONS;
Keywords:
hippocampus; spatial cognition; context recognition; place cells; cognitive map; DNMS; HM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
259
Recensione:
Indirizzi per estratti:
Indirizzo: Redish, AD Univ Minnesota, Dept Neurosci, 6-145 Jackson Hall, Minneapolis,MN 55455 USA Univ Minnesota 6-145 Jackson Hall Minneapolis MN USA 55455 USA
Citazione:
A.D. Redish, "The hippocampal debate: are we asking the right questions?", BEH BRA RES, 127(1-2), 2001, pp. 81-98

Abstract

For years, the debate has been: 'Is the hippocampus the cognitive mapT or 'Is the hippocampus the core of memory? ' These two hypotheses derived theiroriginal power from two key experiments - the cognitive map theory from the remarkable spatial correlates seen in recordings of hippocampal pyramidalcells and the memory theory from the profound amnesias seen in the patientH.M. Both of these key experiments have been reinterpreted over the years:hippocampal cells are correlated with much more than place and H.M. is missing much more than just his hippocampus. However, both theories are still debated today. The hippocampus clearly plays a role in both navigation and memory processing. The question that must be addressed is rather: 'What is the role played by the hippocampus in the navigation and memory systems? ' By looking at the navigation system as a whole, one can identify the major role played by the hippocampus as correcting for accumulation errors that occur within idiothetic navigation systems. This is most clearly experimentally evident as reorientation when an animal is lost. Carrying this over to amore general process, this becomes a role of recalling a context, bridginga contextual gap, or, in other words, it becomes a form of recognition memory. I will review recent experimental data which seems to support this theory over the more general spatial or memory theories traditionally applied to hippocampus. (C) 2001 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:49:21