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Titolo:
Temporal fluctuations of myocardial high-energy phosphate metabolites withthe cardiac cycle
Autore:
Spindler, M; Illing, B; Horn, M; de Groot, M; Ertl, G; Neubauer, S;
Indirizzi:
Univ Wurzburg, Med Klin, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 d Klin, D-97080 Wurzburg, Germany Univ Oxford, John Radcliffe Hosp, Dept Cardiovasc Med, Oxford OX1 2JD, England Univ Oxford Oxford England OX1 2JD rdiovasc Med, Oxford OX1 2JD, England
Titolo Testata:
BASIC RESEARCH IN CARDIOLOGY
fascicolo: 6, volume: 96, anno: 2001,
pagine: 553 - 556
SICI:
0300-8428(200111)96:6<553:TFOMHP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR MAGNETIC-RESONANCE; HEART; RAT; SPECTROSCOPY; INVIVO;
Keywords:
ATP; cardiac cycle; chronic heart failure; energy metabolism; hypoxia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Spindler, M Univ Wurzburg, Med Klin, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080
Citazione:
M. Spindler et al., "Temporal fluctuations of myocardial high-energy phosphate metabolites withthe cardiac cycle", BAS R CARD, 96(6), 2001, pp. 553-556

Abstract

This review describes the temporal changes of high-energy phosphate metabolites during the cardiac cycle. Under baseline condition, the extent of cyclical changes ("cycling") of ATP, phosphocreatine and inorganic phosphate varies between 10-15 %. Such energy oscillations are not augmented under various forms of metabolic stress including 1) inotropic stimulation, 2) acutehypoxia and 3) failing, chronically infarcted hearts. Thus, the concentrations of high-energy phosphates over the cardiac cycle are a tightly regulated entity, even when energetic needs are substantially augmented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 05:22:40