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Titolo:
Focal gray matter density changes in schizophrenia
Autore:
Pol, HEH; Schnack, HG; Mandl, RCW; van Haren, NEM; Koning, H; Collins, DL; Evans, AC; Kahn, RS;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Psychiat, NL-3584 CX Utrecht, Netherlands UnivUtrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada McGill Univ Montreal PQ Canada ontreal Neurol Inst, Montreal, PQ, Canada
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 12, volume: 58, anno: 2001,
pagine: 1118 - 1125
SICI:
0003-990X(200112)58:12<1118:FGMDCI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRUCTURAL BRAIN ABNORMALITIES; CHILDHOOD-ONSET SCHIZOPHRENIA; MAGNETIC-RESONANCE IMAGES; VOXEL-BASED MORPHOMETRY; ORBITOFRONTAL CORTEX; BASAL GANGLIA; VOLUME; AMYGDALA; MEDIODORSAL; THALAMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Pol, HEH Univ Utrecht, Med Ctr, Dept Psychiat, A01-126, NL-3584 CX Utrecht, Netherlands Univ Utrecht A01-126 Utrecht Netherlands NL-3584 CX Netherlands
Citazione:
H.E.H. Pol et al., "Focal gray matter density changes in schizophrenia", ARCH G PSYC, 58(12), 2001, pp. 1118-1125

Abstract

Background: The view that schizophrenia is a brain disease particularly involving decrements in gray matter is supported by findings from many imaging studies. However, it is unknown whether the (progressive) loss of tissue affects the brain globally or whether tissue loss is more prominent in someareas than in others. Methods: Magnetic resonance whole brain images were acquired from 159 patients with schizophrenia or a schizophreniform disorder and 158 healthy subjects across a 55-year age span. Gray matter density maps were made and analyzed using voxel-based morphometry. Results: Compared with healthy subjects, decreases in gray matter density were found in the left amygdala; left hippocampus; right supramarginal gyrus; thalamus; (orbito) frontal, (superior) temporal, occipitotemporal, precuneate, posterior cingulate, and insular cortices bilaterally in patients with schizophrenia or schizophreniform disorder. Compared with healthy subjects, increases in gray matter density were exclusively found in the right caudate and globus pallidus in patients with schizophrenia or schizophreniform disorder. A group-by-age interaction for density was found in the left amygdala, owing to a negative regression slope of gray matter density on age in the left amygdala in patients compared with healthy subjects. Conclusions: Gray matter density is decreased in distinct focal areas in the brains of patients with schizophrenia or schizophreniform disorder, The decreased density in the left amygdala is more pronounced in older patientswith schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:54:59