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Titolo:
Localised disease in cancer of unknown primary (CUP): The value of positron emission tomography (PET) for individual therapeutic management
Autore:
Rades, D; Kuhnel, G; Wildfang, I; Borner, AR; Schmoll, HJ; Knapp, W;
Indirizzi:
Hannover Med Coll, Dept Radiat Oncol, Hannover, Germany Hannover Med CollHannover Germany Dept Radiat Oncol, Hannover, Germany Univ Leipzig, Dept Nucl Med, D-7010 Leipzig, Germany Univ Leipzig Leipzig Germany D-7010 pt Nucl Med, D-7010 Leipzig, Germany Hannover Med Coll, Dept Nucl Med, Hannover, Germany Hannover Med Coll Hannover Germany ll, Dept Nucl Med, Hannover, Germany Univ Halle Wittenberg, Dept Hematol Oncol, Halle Saale, Germany Univ HalleWittenberg Halle Saale Germany l Oncol, Halle Saale, Germany
Titolo Testata:
ANNALS OF ONCOLOGY
fascicolo: 11, volume: 12, anno: 2001,
pagine: 1605 - 1609
SICI:
0923-7534(2001)12:11<1605:LDICOU>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Keywords:
cancer of unknown primary (CUP); positron emission tomography (PET); therapeutic management;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Rades, D Univ Clin Hamburg Eppendorf, Dept Radiotherapy & Radiooncol, Martinistr 52, D-20246 Hamburg, Germany Univ Clin Hamburg Eppendorf Martinistr 52 Hamburg Germany D-20246
Citazione:
D. Rades et al., "Localised disease in cancer of unknown primary (CUP): The value of positron emission tomography (PET) for individual therapeutic management", ANN ONCOL, 12(11), 2001, pp. 1605-1609

Abstract

Background: Two to four percent of cancer patients present with CUP syndrome. Median survival for localised disease is 20 and for disseminated disease, seven months. For localised disease, curative treatment is more likely and individual therapeutic strategies become more important. After conservative diagnostic procedures including MRI, the primary is detected in less than 25%. The diagnostic value of PET and its influence on therapeutic strategies was evaluated. Patients and methods: Forty-two patients with localised CUP were investigated from 5 of 98 to 10 of 2000. The presenting site was lymph node metastasis in 34 and visceral metastasis in 8 patients. After a median of 7 (3-11) diagnostic procedures without detection of the primary, but evidence of localised disease, PET was performed with fluorine-18-fluorodeoxyglucose. Results: In 26 of 42 patients (62%), a primary was suggested by PET and confirmed in 18 (43%). In 5 of 18 patients beyond localised disease, additional dissemination, not detected by previous diagnostic measures, was diagnosed by PET. Overall, dissemination was only detected only by PET in 16 of 42patients (38%). In 29 of 42 patients (69%), the PET result influenced selection of the definitive treatment. Conclusion: In CUP patients, PET has a certain impact on detection of the primary as well as of the disseminated disease, and may also have a certainimpact on therapeutic management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:20:54