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Titolo:
Menstrual cyclic variation of myocardial ischemia in premenopausal women with variant angina
Autore:
Kawano, H; Motoyama, T; Ohgushi, M; Kugiyama, K; Ogawa, H; Yasue, H;
Indirizzi:
Kumamoto Univ, Sch Med, Kumamoto Reg Med Ctr, Dept Cardiovasc Med, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 iovasc Med, Kumamoto 8608556, Japan Kumamoto Aging Res Inst, Kumamoto, Japan Kumamoto Aging Res Inst Kumamoto Japan Aging Res Inst, Kumamoto, Japan
Titolo Testata:
ANNALS OF INTERNAL MEDICINE
fascicolo: 11, volume: 135, anno: 2001,
pagine: 977 - 981
SICI:
0003-4819(200112)135:11<977:MCVOMI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT VASODILATION; CORONARY-ARTERY SPASM; BRACHIAL-ARTERY; SMOOTH-MUSCLE; NITRIC-OXIDE; ACETYLCHOLINE; PATHOGENESIS; ESTROGEN; RELAXATION; DILATATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kawano, H Kumamoto Univ, Sch Med, Kumamoto Reg Med Ctr, Dept Cardiovasc Med, 1-1-1 Honjo, Kumamoto 8608556, Japan Kumamoto Univ 1-1-1 Honjo KumamotoJapan 8608556 8608556, Japan
Citazione:
H. Kawano et al., "Menstrual cyclic variation of myocardial ischemia in premenopausal women with variant angina", ANN INT MED, 135(11), 2001, pp. 977-981

Abstract

Background: An abundance of ovarian hormones is assumed to be a major contributor to the low incidence of ischemic heart disease in premenopausal women. However, the effects of ovarian hormones remain undetermined. Objective: To examine whether the variation in ovarian hormone levels throughout a menstrual cycle affects myocardial ischemia in women with variant angina. Design: Prospective, observational study. Setting: University medical center in Japan. Participants: 10 premenopausal women with variant angina. Measurements: Frequency of spontaneous ischemic episodes, flow-mediated dilation of brachial artery, and serum levels of estradiol and progesterone. Results: Frequency of ischemic episodes was highest from the end of the luteal phase to the beginning of the menstrual phase and was lowest in the follicular phase. Flow-mediated vasodilation and estradiol levels were lowestfrom the end of the luteal phase to the beginning of the menstrual phase and were highest in the follicular phase. Conclusions: in premenopausal women with variant angina, we documented a cyclic variation in endothelial function and the frequency of myocardial ischemia that was associated with the variation in estrogen levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:20:20