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Titolo:
Greater velocity and magnitude of airway narrowing in immature than in mature rabbit lung explants
Autore:
Duguet, A; Wang, CG; Gomes, R; Ghezzo, H; Eidelman, DH; Tepper, R;
Indirizzi:
McGill Univ, Meakins Christie Labs, Div Resp, Montreal, PQ, Canada McGill Univ Montreal PQ Canada stie Labs, Div Resp, Montreal, PQ, Canada McGill Univ, Montreal Chest Inst Res Ctr, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Chest Inst Res Ctr, Montreal, PQ, Canada Indiana Univ, Sch Med, Indianapolis, IN USA Indiana Univ Indianapolis IN USA ana Univ, Sch Med, Indianapolis, IN USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 9, volume: 164, anno: 2001,
pagine: 1728 - 1733
SICI:
1073-449X(20011101)164:9<1728:GVAMOA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAXIMAL PULMONARY RESPONSE; SMOOTH-MUSCLE; SHORTENING VELOCITY; BRONCHIAL RESPONSIVENESS; TRANSPULMONARY PRESSURE; SHEAR MODULUS; METHACHOLINE; TRACHEALIS; MATURATION; ONTOGENY;
Keywords:
rabbit; explants; smooth muscle; lungs; airway;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Tepper, R James Whitcomb Riley Hosp Children, Pediat Pulm Room 2750,702 Barnhill Dr,Indianapolis, IN 46202 USA James Whitcomb Riley Hosp Children Pediat Pulm Room 2750,702 Barnhill Dr Indianapolis IN USA 46202
Citazione:
A. Duguet et al., "Greater velocity and magnitude of airway narrowing in immature than in mature rabbit lung explants", AM J R CRIT, 164(9), 2001, pp. 1728-1733

Abstract

Methacholine (MCh)-induced bronchoconstriction in vivo produces greater maximal increases in pulmonary and airway resistances in immature than in mature rabbits. Our recent findings of lower shear modulus and greater airway distensibility suggest a lower elastic load limiting airway smooth muscle (ASM) shortening in immature rabbit lungs. We hypothesized that a lower elastic load should result in greater velocity of airway narrowing. Lung explants were prepared from three immature and five mature rabbits. Dynamic narrowing of intraparenchymal airways after maximal MCh stimulation. was assessed by video microscopy. Immature airways (n = 80) compared with mature airways (n = 110) demonstrated greater peak velocity of shortening (6.98 +/- 0.32 versus 4.22 +/- 0.18% of baseline perimeter/s) and greater maximal airwaynarrowing, expressed as percentage of baseline area (31.9 +/- 1.6 versus 42.2 +/- 1.8%). For both groups, a greater velocity of shortening resulted in greater airway narrowing. As available data do not support maturational differences in rabbit ASM, our results are consistent with a lower elastic load limiting ASM shortening in the immature rabbit.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 22:18:06