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Titolo:
Pulmonary administration of perfluorodecaline-gentamicin and perfluorodecaline-vancomycin emulsions
Autore:
Franz, AR; Rohlke, W; Franke, RP; Ebsen, M; Pohlandt, F; Hummler, HD;
Indirizzi:
Univ Ulm, Dept Pediat, Div Neonatol & Pedit Crit Care, D-89075 Ulm, Germany Univ Ulm Ulm Germany D-89075 tol & Pedit Crit Care, D-89075 Ulm, Germany Univ Ulm, Dept Biomat, D-89075 Ulm, Germany Univ Ulm Ulm Germany D-89075Univ Ulm, Dept Biomat, D-89075 Ulm, Germany Ruhr Univ Bochum, Dept Pathol, D-4630 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-4630 pt Pathol, D-4630 Bochum, Germany
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 9, volume: 164, anno: 2001,
pagine: 1595 - 1600
SICI:
1073-449X(20011101)164:9<1595:PAOPAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTIAL LIQUID VENTILATION; RESPIRATORY-DISTRESS SYNDROME; CRITICALLY ILL PATIENTS; CYSTIC-FIBROSIS; EXOGENOUS SURFACTANT; INITIAL EXPERIENCE; ADULT PATIENTS; LINING FLUID; LUNG INJURY; PHARMACOKINETICS;
Keywords:
fluorocarbons; mechanical ventilation; antibiotics; drug administration routes; topical administration; gentamicin; vancomycin; bacterial pneumonia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Franz, AR Univ Ulm, Dept Pediat, Div Neonatol & Pedit Crit Care, Prittwitzstr 43, D-89075 Ulm, Germany Univ Ulm Prittwitzstr 43 Ulm Germany D-89075 89075 Ulm, Germany
Citazione:
A.R. Franz et al., "Pulmonary administration of perfluorodecaline-gentamicin and perfluorodecaline-vancomycin emulsions", AM J R CRIT, 164(9), 2001, pp. 1595-1600

Abstract

The aim of this study was to examine pharmacokinetics and pulmonary antibiotic tissue concentrations (PATC) of gentamicin and vancomycin after intrapulmonary administration of a perfluorodecaline (PFD)-gentamicin and a PFD-vancomycin emulsion during partial liquid ventilation (PLV). PLV was initiated in 19 healthy rabbits and 18 surfactant-depleted rabbits. The animals were randomized to receive either 5 mg/kg gentamicin and 15 mg/kg vancomycin intravenously, or 5 mg/kg gentamicin intrapulmonary, or 15 mg/kg vancomycinintrapulmonary. Antibiotic plasma levels were measured after 15, 30, 45, and 60 min, and hourly thereafter. After 5 h animals were sacrificed and lungs were removed to evaluate PATC and histology. PATC were significantly higher after intrapulmonary administration of both gentamicin and vancomycin. In healthy rabbits, peak plasma concentrations were lower and 5 h plasma concentrations were higher after intrapulmonary administration, whereas plasma concentrations were not different in surfactant-depleted rabbits. There were no differences in lung histology, hemodynamics, lung mechanics, or gas exchange between the treatment groups. We conclude that during PLV, higher PATC can be achieved after intrapulmonary administration of PFD-antibiotic emulsions compared with intravenous administration of the same dose withoutapparent short-term adverse effects. We speculate that intrapulmonary antibiotic administration during PLV may be beneficial in treating severe pneumonia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 20:56:53