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Titolo:
Chromosome-12 mapping of late-onset Alzheimer disease among Caribbean Hispanics
Autore:
Mayeux, R; Lee, JH; Romas, SN; Mayo, D; Santana, V; Williamson, J; Ciappa, A; Rondon, HZ; Estevez, P; Lantigua, R; Medrano, M; Torres, M; Stern, Y; Tycko, B; Knowles, JA;
Indirizzi:
Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ergievsky Ctr, New York, NY 10032 USA Columbia Univ, Taub Inst Alzheimers Dis & Aging Brain, New York, NY 10032 USA Columbia Univ New York NY USA 10032 & Aging Brain, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 , Dept Neurol, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ New York NY USA 10032 Dept Psychiat, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Med, New York, NY 10032 USA ColumbiaUniv New York NY USA 10032 urg, Dept Med, New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Pathol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 , Dept Pathol, New York, NY 10032 USA Columbia Univ, Sch Publ Hlth, Div Epidemiol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 Div Epidemiol, New York, NY 10032 USA Columbia Univ, Columbia Genome Ctr, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ia Genome Ctr, New York, NY 10032 USA Univ Tecnol Santiago, Santiago, Dominican Rep Univ Tecnol Santiago Santiago Dominican Rep go, Santiago, Dominican Rep Plaza Salud Hosp, Santo Domingo, Dominican Rep Plaza Salud Hosp Santo Domingo Dominican Rep nto Domingo, Dominican Rep
Titolo Testata:
AMERICAN JOURNAL OF HUMAN GENETICS
fascicolo: 1, volume: 70, anno: 2002,
pagine: 237 - 243
SICI:
0002-9297(200201)70:1<237:CMOLAD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARADIGM-BASED DIAGNOSIS; LINKAGE ANALYSIS; PROTEIN GENE; HETEROGENEOUS POPULATION; APOLIPOPROTEIN-E; POLYMORPHISM; ALPHA-2-MACROGLOBULIN; ASSOCIATION; DEMENTIA; LOCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Mayeux, R Columbia Univ, Gertrude H Sergievsky Ctr, 630 W 168th St, New York, NY 10032 USA Columbia Univ 630 W 168th St New York NY USA 10032 NY 10032 USA
Citazione:
R. Mayeux et al., "Chromosome-12 mapping of late-onset Alzheimer disease among Caribbean Hispanics", AM J HU GEN, 70(1), 2002, pp. 237-243

Abstract

Linkage to chromosome 12p for familial Alzheimer disease (AD) has been inconsistent. Using 35 markers near the centromere of chromosome 12, we investigated 79 Caribbean Hispanic families with AD. Two-point linkage analysis using affected sib pairs yielded LOD scores of 3.15 at D12S1623 and 1.43 at D12S1042. The LOD score at D12S1623 decreased to 1.62 in families with late-onset (age > 65 years) AD (LOAD), but the LOD score at D12S1042 was unchanged. Among families negative for the apolipoprotein E (APOE-epsilon4) allele, the LOD score for D12S1623 was lower (1.01), whereas that for D12S1042 increased to 1.73. Among families positive for the APOE-epsilon4 allele, none of the LOD scores reached 1. Multipoint affected-relative-pair analysis showed peaks at D12S1623 (nonparametric linkage [NPL] score 1.52; P = .028) and near D12S1042, at D12S1057 (NPL score 1.57; P = .027). NPL scores for both D12S1623 and D12S1057 increased in families affected with LOAD, but, inAPOE-epsilon4-negative families, only scores for the region flanking D12S1623 remained elevated (NPL score 1.74; P = .013). This study of Caribbean Hispanics with familial AD extends and provides modest evidence of linkage to loci on chromosome 12p. Linkage varied by age at onset of AD and by the presence or absence of the APOE-epsilon4 allele.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/12/19 alle ore 01:34:57