Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population withasthma
Autore:
Howard, TD; Koppelman, GH; Xu, JF; Zheng, SQL; Postma, DS; Meyers, DA; Bleecker, ER;
Indirizzi:
Wake Forest Univ, Bowman Gray Sch Med, Ctr Human Genome, Winston Salem, NC27157 USA Wake Forest Univ Winston Salem NC USA 27157 e, Winston Salem, NC27157 USA Univ Groningen Hosp, Dept Pulmonol, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands monol, Groningen, Netherlands Beatrixoord, Dept Pulm Rehabil, Haren, Netherlands Beatrixoord Haren Netherlands rd, Dept Pulm Rehabil, Haren, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF HUMAN GENETICS
fascicolo: 1, volume: 70, anno: 2002,
pagine: 230 - 236
SICI:
0002-9297(200201)70:1<230:GIIAIA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN-TEST REACTIVITY; SERUM IGE LEVELS; INTERLEUKIN-4 RECEPTOR; AIRWAY INFLAMMATION; BRONCHIAL RESPONSIVENESS; IL4-RECEPTOR GENE; ATOPIC ASTHMA; ALPHA-GENE; ASSOCIATION; IL-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Bleecker, ER Wake Forest Univ, Bowman Gray Sch Med, Ctr Human Genome, Med Ctr Blvd, Winston Salem, NC 27157 USA Wake Forest Univ Med Ctr Blvd WinstonSalem NC USA 27157 USA
Citazione:
T.D. Howard et al., "Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population withasthma", AM J HU GEN, 70(1), 2002, pp. 230-236

Abstract

Asthma is a common respiratory disease that is characterized by variable airways obstruction caused by acute and chronic bronchial inflammation; associated phenotypes include bronchial hyperresponsiveness (BHR), elevated total serum immunoglobulin E (IgE) levels, and skin tests positive to common allergens. Binding of interleukin-13 (IL13) or interleukin-4 (IL4) to the IL4 receptor (IL4R) induces the initial response for Th2 lymphocyte polarization. Both IL13 and IL4 are produced by Th2 cells and are capable of inducing isotype class-switching of B-cells to produce IgE after allergen exposure. These cytokines also share a common receptor component, IL4R. We have investigated five IL4RA single-nucleotide polymorphisms in a population of Dutch families ascertained through a proband with asthma. By considering the probands and their spouses as an unrelated sample, we observed significant associations of atopy and asthma-related phenotypes with several IL4RA polymorphisms, including S478P and total serum IgE levels (P=.0007). A significant gene-gene interaction between S478P in IL4RA and the - 1111 promoter variation in IL13, previously shown to be associated with BHR (P = .003), was detected. Individuals with the risk genotype for both genes were at almost five times greater risk for the development of asthma compared to individuals with both nonrisk genotypes (P = .0004). These data suggest that variations in IL4RA contribute to elevated total serum IgE levels, and interactionbetween IL4RA and IL13 markedly increases an individual's susceptibility to asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/12/19 alle ore 14:50:29