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Titolo:
Likelihood formulation of parent-of-origin effects on segregation analysis, including ascertainment
Autore:
Haghighi, F; Hodge, SE;
Indirizzi:
New York State Psychiat Inst & Hosp, Unit 24, New York, NY 10032 USA New York State Psychiat Inst & Hosp New York NY USA 10032 k, NY 10032 USA Columbia Univ, Coll Phys & Surg, Columbia Genome Ctr, New York, NY USA Columbia Univ New York NY USA urg, Columbia Genome Ctr, New York, NY USA Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA Columbia Univ New York NY USA ys & Surg, Dept Psychiat, New York, NY USA Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY USA Columbia Univ New York NY USA Publ Hlth, Dept Biostat, New York, NY USA
Titolo Testata:
AMERICAN JOURNAL OF HUMAN GENETICS
fascicolo: 1, volume: 70, anno: 2002,
pagine: 142 - 156
SICI:
0002-9297(200201)70:1<142:LFOPEO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPOINT LINKAGE ANALYSIS; PANIC DISORDER; TOURETTES-SYNDROME; MITOCHONDRIAL-DNA; BIPOLAR DISORDER; PEDIGREE DATA; TRANSMISSION; DISEASE; CHROMOSOME-18; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Hodge, SE New York State Psychiat Inst & Hosp, Unit 24, 1051 Riverside Dr,New York,NY 10032 USA New York State Psychiat Inst & Hosp 1051 Riverside Dr New York NY USA 10032
Citazione:
F. Haghighi e S.E. Hodge, "Likelihood formulation of parent-of-origin effects on segregation analysis, including ascertainment", AM J HU GEN, 70(1), 2002, pp. 142-156

Abstract

We developed a likelihood-based method for testing for parent-of-origin effect in complex diseases. The likelihood formulations model parent-of-origin effect and allow for incorporation of ascertainment, as well as differential male and female ascertainment probabilities. The results based on simulated data indicated that the estimates of parental effect (either maternal or paternal) were biased when ascertainment was ignored or when the wrong ascertainment model was used. The exception was single ascertainment, in which we proved that ignoring ascertainment does not bias the estimation of parental effect, in a simple parent-of-origin model. These results underscorethe importance of considering ascertainment models when testing for parent-of-origin effect in complex diseases.

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Documento generato il 06/04/20 alle ore 10:24:48