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Titolo:
Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study
Autore:
Feitosa, MF; Borecki, IB; Rich, SS; Arnett, DK; Sholinsky, P; Myers, RH; Leppert, M; Province, MA;
Indirizzi:
Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Div Biostat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Genet, St Louis, MO 63110 USA Wake Forest Univ, Sch Med, Dept Publ Hlth Sci, Winston Salem, NC USA Wake Forest Univ Winston Salem NC USA bl Hlth Sci, Winston Salem, NC USA Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 demiol, Minneapolis, MN 55455 USA NHLBI, Epidemiol & Biometry Program, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 Biometry Program, NIH, Bethesda, MD 20892 USA Boston Univ, Sch Med, Prevent Med & Epidemiol Sect, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 ed & Epidemiol Sect, Boston, MA 02118 USA Univ Utah, Eccles Inst Human Genet, Salt Lake City, UT USA Univ Utah SaltLake City UT USA Inst Human Genet, Salt Lake City, UT USA
Titolo Testata:
AMERICAN JOURNAL OF HUMAN GENETICS
fascicolo: 1, volume: 70, anno: 2002,
pagine: 72 - 82
SICI:
0002-9297(200201)70:1<72:QLIBIR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR GENE POLYMORPHISM; AUTOSOMAL GENOMIC SCAN; RESTING METABOLIC-RATE; SIB-PAIR ANALYSIS; HUMAN OB GENE; QUEBEC FAMILY; LINKAGE ANALYSIS; EXTREME OBESITY; RESPIRATORY QUOTIENT; SUSCEPTIBILITY LOCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Feitosa, MF Washington Univ, Sch Med, Div Biostat, Campus Box 8067,660 S Euclid, St Louis, MO 63110 USA Washington Univ Campus Box 8067,660 S Euclid St Louis MO USA 63110
Citazione:
M.F. Feitosa et al., "Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study", AM J HU GEN, 70(1), 2002, pp. 72-82

Abstract

Obesity is a risk factor for many chronic diseases, including glucose intolerance, lipid disorders, hypertension, and coronary heart disease. Even though the body-mass index (BMI) is a heterogeneous phenotype reflecting the amount of fat, lean mass, and body build, several studies have provided evidence of one or two major loci contributing to the variation in this complex trait. We sought to identify loci with potential influence on BMI in the data obtained from National Heart, Lung, and Blood Institute Family Heart Study. Two complementary samples were studied: (a) 1, 184 subjects in 317 sibships, with 243 markers typed by the Utah Molecular Genetics Laboratory (UMGL) and (b) 3,027 subjects distributed among 401 three-generation families, with 404 markers typed by the Mammalian Genotyping Service (MGS). A genome scan using a variance-components-based linkage approach was performed foreach sample, as well as for the combined sample, in which the markers fromeach analysis were placed on a common genetic map. There was strong evidence for linkage on chromosome 7q32.3 in each sample: the maximum multipoint LOD scores were 4.7 (P<10(-3)) at marker GATA43C11 and 3.2 (P = .00007) at marker D7S1804, for the MGS and UMGL samples, respectively. The linkage result is replicated by the consistent evidence from these two complementary subsets. Furthermore, the evidence for linkage was maintained in the combined sample, with a LOD score of 4.9 (P<10(-5)) for both markers, which map tothe same location. This signal is very near the published location for theleptin gene, which is the most prominent candidate gene in this region. For the combined-sample analysis, evidence of linkage was also found on chromosome 13q14, with D13S257 (LOD score 3.2, P = .00006), and other, weaker signals (LOD scores 1.5-1. 9) were found on chromosomes 1, 2, 3, 5, 6, 14, and 15.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:15:25