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Titolo:
Genomewide linkage analysis of celiac disease in Finnish families
Autore:
Liu, JJ; Juo, SH; Holopainen, P; Terwilliger, J; Tong, XM; Grunn, A; Brito, M; Green, P; Mustalahti, K; Maki, M; Gilliam, TC; Partanen, J;
Indirizzi:
Finnish Red Cross Blood Transfus Serv, Dept Tissue Typing, Helsinki 00310,Finland Finnish Red Cross Blood Transfus Serv Helsinki Finland 00310 310,Finland Columbia Univ, Columbia Genome Ctr, New York, NY USA Columbia Univ New York NY USA niv, Columbia Genome Ctr, New York, NY USA Columbia Univ, Dept Psychiat, New York, NY USA Columbia Univ New York NY USA mbia Univ, Dept Psychiat, New York, NY USA Columbia Univ, Dept Med, New York, NY USA Columbia Univ New York NY USAColumbia Univ, Dept Med, New York, NY USA Columbia Univ, Dept Genet & Dev, New York, NY USA Columbia Univ New York NY USA a Univ, Dept Genet & Dev, New York, NY USA New York State Psychiat Inst & Hosp, New York, NY 10032 USA New York StatePsychiat Inst & Hosp New York NY USA 10032 k, NY 10032 USA Univ Tampere, Sch Med, FIN-33101 Tampere, Finland Univ Tampere Tampere Finland FIN-33101 h Med, FIN-33101 Tampere, Finland Tampere Univ Hosp, Tampere, Finland Tampere Univ Hosp Tampere FinlandTampere Univ Hosp, Tampere, Finland
Titolo Testata:
AMERICAN JOURNAL OF HUMAN GENETICS
fascicolo: 1, volume: 70, anno: 2002,
pagine: 51 - 59
SICI:
0002-9297(200201)70:1<51:GLAOCD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC CONTRIBUTION; HUMAN-POPULATIONS; HLA-DR; REGION; SUSCEPTIBILITY; DISEQUILIBRIUM; FINLAND; ERRORS; ASSOCIATION; ALLELES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Partanen, J Finnish Red Cross Blood Transfus Serv, Dept Tissue Typing, Kivihaantie 7, Helsinki 00310, Finland Finnish Red Cross Blood Transfus Serv Kivihaantie 7 Helsinki Finland 00310
Citazione:
J.J. Liu et al., "Genomewide linkage analysis of celiac disease in Finnish families", AM J HU GEN, 70(1), 2002, pp. 51-59

Abstract

Celiac disease (CD), or gluten-sensitive enteropathy, is a common multifactorial disorder resulting from intolerance to cereal prolamins. The only established genetic susceptibility factor is HLA-DQ, which appears to explainonly part of the overall genetic risk. We performed a genomewide scan of CD in 60 Finnish families. In addition to strong evidence for linkage to theHLA region at 6p21.3 (Z(max)>5), suggestive evidence for linkage was foundfor six other chromosomal regions-1p36, 4p15, 5q31, 7q21, 9p21-23, and 16q12. We further analyzed the three most convincing regions-4p15, 5q31, and 7q21- by evaluation of dense marker arrays across each region and by analysis of an additional 38 families. Although multipoint analysis with dense markers provided supportive evidence (multipoint LOD scores 3.25 at 4p15, 1.49at 5q31, and 1.04 at 7q21) for the initial findings, the additional 38 families did not strengthen evidence for linkage. The role that HLA-DQ plays was studied in more detail by analysis of DQB1 alleles in all 98 families. All but one patient carried one or two HLA-DQ risk alleles, and 65% of HLA-DQ2 carriers were affected. Our study indicates that the HLA region harbors a predominant CD-susceptibility locus in these Finnish families.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/12/19 alle ore 15:03:20